几种药物对大鼠过敏性气道炎症的抑制作用  

Effect of various drugs on airway allergic inflammation in Sprague Dawley rats

作　　者：赵孟辉[1] 张丽芬[1] 张纬萍[1] 魏尔清[1] 

机构地区：[1]浙江医科大学神经生物学实验室

出　　处：《中国药理学与毒理学杂志》1997年第4期267-270,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金;浙江省分析测试基金

摘　　要：在Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ大鼠过敏性气道炎症模型上观察不同药物的抗炎作用。ｉｐ地塞米松（０．５ｍｇ·ｋｇ－１），粉防己碱（３０ｍｇ·ｋｇ－１）以及非肽类神经速激肽受体拮抗剂ＣＰ－９６３４５和ＳＲ－４８９６８（各１ｍｇ·ｋｇ－１），每日２次，连续３ｄ，可抑制卵白蛋白１ｍｇ致敏大鼠吸入抗原后６ｈ或２４ｈ肺灌洗液中的白细胞数量增多，明显减轻细支气管和小血管周围嗜酸性细胞浸润及管壁水肿等炎症状况。结果证明大鼠模型可以作为评价平喘药作用的工具，并提示速激肽参与气道过敏性炎症。The anti inflammatory effects of various drugs were observed in a Sprague Dawley (SD) rat model of airway allergic inflammation. Intraperitoneal injections of dexamethasone (0.5 mg·kg 1 ), tetrandrine (30 mg ·kg 1 ) and a combination of nonpeptide tachykinin receptor antagonists, CP 96345 and SR 48968 (1 mg·kg 1 , respectively), twice a day for 3 d, significantly decreased the ovalbumin (OA, 1 mg) aerosol induced increases in leukocyte numbers in the bronchoalveolar lavage fluid, edema of airway walls, and infiltration of eosinophils around the bronchioles and vessels 6 and 24 h after inhalation in the OA sensitized SD rats. This result indicates the usefulness of SD rat allergic airway inflammation as a model for evaluation of the anti inflammatory effects of anti asthmatic drugs, and the involvement of endogenous tachykinins in the allergic airway inflammation.

关 键 词：过敏性气道炎症 哮喘 CP-96345 地塞米松 治疗 

分 类 号：R562.250.5[医药卫生—呼吸系统] R974.3[医药卫生—内科学]