辅酶Q_(10)对过量对乙酰氨基酚所致小鼠肝损伤的预防作用  

Preventive effect of coenzyme Q 10 on hepatic damage caused by overdosage of paracetamol in mice

作　　者：黎煌久[1] 陈焕昭[1] 吴惜贞[1] 刘幸平[1] 

机构地区：[1]汕头大学医学院

出　　处：《中国药理学与毒理学杂志》1997年第4期278-280,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：本实验结果表明，小鼠预先用辅酶Ｑ１０ｓｃ，能对抗过量对乙酰氨基酚（Ｐａｒ）所致的小鼠肝糖原含量下降和肝损伤引起的谷丙转氨酶（ＧＰＴ）活性升高及病理组织学变化；同时也发现Ｑ１０能使小鼠血清Ｐａｒ浓度和肝匀浆谷胱甘肽（ＧＳＨ）含量升高，而对小鼠肝匀浆细胞色素Ｐ４５０含量没有影响．The effects of coenzyme Q 10 on liver damage in mice induced by the overdosage of paracetamol are described. The results showed that CoQ 10 decreased the activity of serum glutamic pyruvic transaminase, increased the content of hepatic glycogen and ameliorated the pathological changes of hepatic damage due to overdosage of paracetamol in mice. It was also indicated in this paper that CoQ 10 could cause the increase in serum paracetamol concentration and glutathione content, but the content of hepatic microsome cytochrome P450 did not change. It is suggested that the mechanism of CoQ 10 preventive effect on hepatic damage might be regarded as the increase in stability of hepatic microsome membrane.

关 键 词：肝损伤 对乙酰氮基酚 辅酶Q10 预防 谷胱甘肽 

分 类 号：R977.3[医药卫生—药品]