广东省江门市广州管圆线虫病流行病学调查  

Epidemiological Investigation of Angiostrongylus cantonensis in Jiangmen of Guangdong Province

作　　者：张赟[1] 黄迪[1] 谭启明[1] 陈代雄[1] 詹希美[2] 

机构地区：[1]广州医学院病原生物学教研室,广州510182 [2]中山大学中山医学院寄生虫学教研室,广州510080

出　　处：《中国寄生虫学与寄生虫病杂志》2008年第5期370-373,共4页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金-广东省人民政府联合基金资助项目(No.U0632003)~~

摘　　要：目的对广东省江门市广州管圆线虫病进行流行病学调查。方法2006-2007年在广东省江门市礼乐镇和五邑大学及新会市三江镇和双水镇,调查广州管圆线虫不同宿主感染情况和特征,包括用消化法检测褐云玛瑙螺(Achatina fulica)和福寿螺(Pomacea canaliculata)感染广州管圆线虫(Angiostrongylus cantonensis)Ⅲ期幼虫情况;解剖褐家鼠(Rattus norvegicus)、板齿鼠(Bandicota indica)和黄胸鼠(Rattus flavipectus)心、肺,检查心肺血管中广州管圆线虫成虫感染率;随机抽样问卷调查当地居民广州管圆线虫病史及饮食习惯等。ELISA检测300份居民血清广州管圆线虫特异性IgG和IgM抗体阳性率。结果检查褐云玛瑙螺695只,福寿螺720只,其广州管圆线虫Ⅲ期幼虫阳性率分别为45.0%和1.8%;平均感染度分别为53.74±147.30条/只和5.23±8.51条/只。检查鼠类229只,广州管圆线虫成虫感染率为4.4%。问卷调查300人,其中11.3%有食生或半生鱼、虾史,5.3%在劳动中直接或间接接触过褐云玛瑙螺和福寿螺。检查300份居民血清,IgG抗体阳性42份,阳性率为14.0%,其中IgM抗体阳性5份,阳性率为1.7%。结论江门市为广州管圆线虫病流行区,居民受到该病的威胁。Objective To make an epidemiological survey on Angiostrongylus cantonensis in Jiangmen City of Guangdong Province. Methods From October 2006 to November 2007, the characteristics of A. cantonensis infection were investigated in Jiangmen district in various hosts, including the third stage larva infection in the snails Achcaina fulica and Pomocea cctnaliculata by digestion method, and the adult A. cantonensis in rats by the dissection of heart and lungs. Relevant symptoms and dietary habits in Jiangmen residents who were randomly recruited were also investigated by questionnaire, and the specific IgG and IgM antibodies against A. cantonensis in their sera were detected by ELISA. Results 695 A. fulica and 720 P. canaliculata were examined. The infection rate of third stage larva of A. cantonensis were 45.0% and 1.8% respectively, with an infectiosity of 53.74±147.30 and 5.23±8.51 respectively. Natural infection rate of A. cantonensis in all 229 rats was 4.4%. Among the 300 people surveyed, 1 1.3% had a history of eating raw or undercooked fish and shrimp, 5.3% directly or indirectly exposed to A. fulica or P. canaliculata. The positive rate of specific lgG antibody against A.cantonensis for serum samples among residents was 14.0% （42/300）, and 5 serum samples in the 42 positive samples showed specific IgM antibody, with a positive rate of 1.7%. Conclusion Jiangmen district is an endemic area of A. cantonensis, and the local residents are under the risk of infection.

关 键 词：广州管圆线虫 流行病学 褐云玛瑙螺 福寿螺 江门市 

分 类 号：R532.19[医药卫生—内科学]