5项炎性因子在冠心病中的表达及临床意义  

Changes in levels of inflammatory factors and their clinical significance in patients with coronary heart disease.

作　　者：刘明[1] 庞永诚[1] 杨汝文[1] 龚瑞芸[1] 魏丹霞[1] 陈斌[1] 

机构地区：[1]昆明市中医医院,云南昆明650011

出　　处：《云南医药》2008年第5期439-442,共4页Medicine and Pharmacy of Yunnan

基　　金：昆明市科委2005年的资助课题

摘　　要：目的通过对冠心病(CHD)患者超敏C反应蛋白(Hs-CRP),白介素-1(IL-1),白介素-6(IL-6),可溶性细胞粘附因子-1(sICAM-1)及可溶性血管细胞粘附因子-1(sVCAM-1)5项炎性因子的临床及实验研究。探讨5项炎性因子在CHD中的诊断及应用价值。方法将111例CHD患者分成3组,急性心肌梗死(AMI)组18例,不稳定型心绞痛(UA)组22例,稳定型心绞痛(SAP)组71例,另选择同期健康体检者30例为对照组。进行5项炎性因子的对比分析。结果3组Hs-CRP组间对比有非常显著性差异(P<0.01),IL-6及sICAM-1在AMI组及UA组与正常组对比(P<0.05)有显著差异,余组间两两比较P<0.01;IL-1及sVCAM-1在SAP组与对照组比较P<0.05,AMI组与UA组比较无差异(P>0.05),UA组与SAP组比较无差异(P>0.05)。结论炎症参与了冠心病的发生和发展,Hs-CRP,IL-6及sICAM-1可作为判断冠心病患者病情严重的参考指标。而IL-1及sVCAM-1在判断冠心病的病情严重程度上的价值有待进一步探讨研究。Objective To explore the applicated value of serum high-sensitivity G-reactive protein （hs-CRP）, interleukin-1 （IL-1） , interleukin-6 （IL-6） , soluble intercellular adhesion molecule-1 （sICAM-1） and soluble vascular cell adhesion molecule-1 （sVCAM-1） in the diagnosis of coronary heart disease （CHD）. Methods One hundred and eleven patients with CHD were divided into three groups ： acute myocardial infarction （AMI） group（n = 18）, unstable angina （UA） group （n=22）, and stable angina pectoris （SAP） group （n=71）. 30 volunteers were selected as controls . Serum levels of inflammatory factors were measured by enzyme-linked immunosorbent assay. Results Serum hs-CRP levels were significantly different in all groups （P〈0.01）. Compared with health subjects, serum IL-6 and sICAM-1 were significantly increased in AMI group and UA group （P〈0.05）. Compared with health subjects, IL-1 and sVCAM-1 were significantly different from UA group （P〈0.05） ,but there were no significant differences between AMI group and UA group （P〉0.05）, and betweem UA group and SAP group （P〉0.05）. Conclusion The inflammatory reaction should play an important role in CHD process. Hs-CRP, IL-6 and sICAM-1 are promising markers for the risk assessment in CHD. There might be a relation between IL-1 and VCAM-1 levels and the severe degree of CHD, that needs to be confirmed in the further investigations.

关 键 词：冠心病 C反应蛋白 白介素 可溶性细胞粘附因子 病情严重程度 

分 类 号：R541.4[医药卫生—心血管疾病]