老年高血压糖尿病患者脉压和颈动脉内膜中层厚度的关系  

Relationship between office pulse pressure and carotid intima-media thickness in senile patients with hypertension and diabetes

作　　者：梁伟[1] 王巍[1] 沈琳辉[1] 金翠燕[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院老年病科,上海200025

出　　处：《中华老年心脑血管病杂志》2008年第11期807-809,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：上海市科学技术委员会科研项目（024119129）

摘　　要：目的探讨脉压对老年高血压合并糖尿病患者颈动脉内膜中层厚度（IMT）的影响。方法230例高血压患者根据病因分组，将高血压伴2型糖尿病患者分为合并糖尿病纽（100例），未合并糖尿病的高血压患者分为高血压组（130例）。测量血压，进行颈部动脉超声检查，测量颈动脉IMT，测定空腹血糖、胰岛素，并行单因素相关分析。结果合并糖尿病组患者颈动脉IMT为（0．67±0．08）mm，脉压为（61．93±14．55）mmHg（1mmHg=0．133kPa），均较高血压组明显升高[（0．50±0．03）mm，（55．76±12．98）mmHg，P〈0．01]，合并糖尿病组患者胰岛素敏感指数（ISI，-3．68±0．82）较高血压组（-2．96±0．95）明显降低（P〈0．01）。相关分析显示，IMT与脉压呈正相关，与ISI呈负相关。结论脉压和胰岛素抵抗与高血压合并糖尿病患者颈动脉IMT密切相关。Objective To investigate the impact of office pulse pressure（PP） on carotid structure in elderly patients with essential hypertension（EH） and type-2 diabetes mellitus（DM）. Methods 230 hypertensive patients were divided into 2 groups： type-2 DM complicated with EH （DM ＋ EH） group, and EH group, All subjects underwent blood pressure measurement and ultrasonograpby of carotid arteries to measure the intima-media thickness（IMT）. The biochemical parameters such as fasting glucose and insulin were tested. Results IMT was higher in DM＋EH group that in EH group. There was a positive correlation between PP and IMT. Insulin sensitivity index （ISI） was negatively correlated to IMT. Conclusion PP and ISI are closely correlated to carotid IMT in DM＋EH patients.

关 键 词：高血压 糖尿病 颈动脉 血管内膜 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病]