CCK-B受体拮抗剂L-365,260翻转100Hz慢性电针耐受  

CHRONIC ELECTROACUPUNCTURE (EA) TOLERANCE REVERSED BY CCK-B ANTAGONIST L-365, 260

作　　者：王晓民[1] 董艺娜 石瑞丽[2] 韩济生[1] 

机构地区：[1]北京医科大学神经科学研究中心,北京100083 [2]内蒙古包头医学院生理教研室

出　　处：《中国疼痛医学杂志》1997年第4期228-232,共5页Chinese Journal of Pain Medicine

基　　金：自然科学基金!39470232

摘　　要：48只高针效大鼠随机分为6组，每组大鼠（8只）每天给予100Hz电针一次（30min），连续6天。其电针镇痛效果逐渐降低，形成慢性电针耐受。在第7天，6组大鼠分别皮下（S．C．）注射配药液或不同剂量的CCK－B受体桔抗剂L－365，260（0．03～3mg／kg）。S．C．注射配药液的对照大鼠仍然表现出明显的电针耐受现象，而s.c.注射L－365，260（0．1mg，0．3mg／kg）则可以有效地翻转100Hz慢性电针耐受，剂量太小（0．03mg／kg）或太大（1mg，3mg／kg）时均无效。换言之，L－365，260翻转100Hz慢性电针耐受的剂量效应曲线呈钟形曲线。上述结果表明，中枢内源性CCK参与100Hz慢性电针耐受的形成。48 rats were randomly and evenly divided into six groups. 100 Hz EA was administered for each group once a day (30 min) for 6 consecutive days. There was a gradual decrease in EA effect following repeated EA stimulation, indicating the development of chronic EA tolerance. In the seventh day, vehicle or different doses of CCK-B antagonist L-365, 260 (0. 03～3mg/ kg) was administered by subcutaneous (s. c. ) injection. Rats treated with vehicle exhibited significant tolerance to EA. In contrast, L-365, 260 at doses of 0. 1 mg, 0. 3 mg/ kg, but not 0.03 mg/ kg nor 1 or 3 mg/ kg,can effectively reverse the development of 100 Hz EA tolerance, showing a belLshaped dose response curve. These results suggest that endogenous cholecystokinin is involved in the development of chronic 100 Hz EA tolerance.

关 键 词：CCK-B受体 拮抗剂 耐受 电针镇痛 

分 类 号：R338.3[医药卫生—人体生理学] R245.97[医药卫生—基础医学]