原位肝移植术后急性肺损伤的研究进展  

Advance in acute lung injury following orthotopic liver transplantation

作　　者：黎尚荣[1] 黑子清[1] 陈规划[2] 

机构地区：[1]中山大学附属第三医院麻醉科,广州510630 [2]中山大学附属第三医院肝脏移植中心

出　　处：《国际麻醉学与复苏杂志》2008年第5期410-413,共4页International Journal of Anesthesiology and Resuscitation

基　　金：广东省科技计划项目（2004B35001005）

摘　　要：急性肺损伤（acute lung injury，ALI）是原位肝移植术（orthotopic liver transplant，OLT）后常见的并发症，是术后医院时间延长及死亡率增加的重要原因。ALI的诊断标准是氧合指数（分氧压／吸氧浓度）〈300，肺小动脉楔压〈18mmHg，X先示肺部浸润征。ALI可发展成为急性呼吸窘迫综合征（acute respiratory distress syndrome，ARPS），其诊断除氧合指数〈200外，其他与ALI相同，此文对OLT术后ALI的发生，临床因素及机制作一综述。Acute lung injury （ALI） is one of postoperative complications derived from orthotopic liver transplant （ OLT）, with high morbidity and high mortality. ALI is defined as a syndrome including bilateral pulmonary infiltration on chest X-ray, pulmonary capillary wedge pressure 〈 18 mm Hg and PaO2/FiO2 〈 300. The term ＂ALl＂ has been used as an umbrella term for hypoxemic respiratory failure, the severe version of which is （ARDS）. The definition of ARDS is same as ALI except of PaO2/FiO2 〈 20, instead of 〈 300. This article will review the mechanisms of ALI to occur and the clinical factors probably involved in ALI.

关 键 词：急性肺损伤 急性呼吸窘迫综合征 原位肝移植 机制 

分 类 号：R657.3[医药卫生—外科学] R614[医药卫生—临床医学]