慢性肾衰血透患者骨代谢的评估  

Evaluation of Bone Metabolism in Patients with Chronic Renal Failure Maintained by Hemodialysis

作　　者：章俊[1] 曾熙兰[2] 曾莉 徐钟源[2] 

机构地区：[1]第一军医大学珠江医院,广州510282 [2]中山医科大学放免中心 [3]广州军区医学高等专科学校

出　　处：《标记免疫分析与临床》1997年第3期139-142,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：用IRMA、RRA和RIA等对24例维持血透患者（MHD）测定其血甲状旁腺激素、PTH（l～84）、25（OH）D3、1，25（OH）2D3、BGP、血钙和磷的变化，以探讨它们之间的关系和评估患者骨代谢的状况。MHD患者PTH和BGP升高，透析后则降低；25（（）H）fa和1，25（（）H）。D3降低，透析对其无明显影响；PTH与25（（）H）D3、l，25（（）H）。D3呈负相关，P分别小于0．05和0．01；PTH与BGP呈正相关（P＜0．of）。PTH分泌亢进是骨代谢紊乱的主要因素，MHD患者骨转化率增高。The changes of PTH, 25(OH)D3, 1, 25(OH)2D3, BGP, Ca and P levels in the blood of 24 hemodialysis patients and their relationship were investigated by IRMA, RRA and RIA. PTH and BGP were increased in HD patients and decreased after hemodialysis. 25(OH)D3and 1, 25 (OH)2D3 were decreased in patients, but their levels were not changed further after hemodialysis. PTH had both a negative correlation with 25(OH)D3 (r=-0. 391, P < 0. 05) or 1, 25(OH)2D3(r=-0. 493, P< 0. 01), and a positive correlation with BGP (r=0. 517, P<0.01) in HD patients. PTH hypersecretion is a main factor inducing bone metabolism disturbance and bone turnover rate is increased in these patients.

关 键 词：肾功能衰竭 慢性 血液透析 骨代谢 

分 类 号：R692.504[医药卫生—泌尿科学] R459.5[医药卫生—外科学]