ABCA1与NPC1在细胞内胆固醇转运中的作用  

Roles of ABCA1 and NPC1 in intracellular cholesterol transport

作　　者：李晓旭[1] 唐朝克[1] 

机构地区：[1]南华大学心血管病研究所动脉硬化学湖南省重点实验室生命科学研究中心,衡阳421001

出　　处：《生命的化学》2008年第5期633-636,共4页Chemistry of Life

基　　金：国家自然科学基金(30470720);湖南省自然科学基金(06jj5058)资助

摘　　要：腺苷三磷酸结合盒转运蛋白A1(ATP-binding cassette transporter A1,ABCA1)是血浆高密度脂蛋白(high-density lipoprotein,HDL)颗粒形成之初的限速步骤。ABCA1通过膜泡运输脂质至细胞表面的HDL载脂蛋白的作用机制尚未完全阐明。C型尼曼-匹克病(Niemann-Pick disease type C,NPC)主要由NPC1基因突变引起,NPC1蛋白能促进胆固醇和其他脂质从晚期胞内体/溶酶体流入其他细胞结构。ABCA1和NPC1相互作用保持细胞内脂质平衡,与Tangier病和N C P病等病理过程密切相关。The membrane transporter ATP-binding Cassette transporter A1 （ABCA1） has been shown to be the rate-limiting step in the initial formation of plasma high-density lipoprotein （HDL） particles. The mechanisms of action of ABCA1, including its role in the vesicular transport of lipids to the cell surface for the lipidation of HDL apolipoproteins, are not fully understood. Niemann-Pick type C （NPC） disease is most often caused by mutations in the NPC1 gene, whose protein product is believed to facilitate the egress of cholesterol and other lipids from late endosomes and lysosomes to other cellular compartments. The interaction between ABCA1 and NPC1 can maintain the balance of cellular lipids, which is associated with many pathology process including Tangier disease and NPC disease.

关 键 词：腺苷三磷酸结合盒转运蛋白A1 高密度脂蛋白 NPC1 胆固醇流出 

分 类 号：Q51[生物学—生物化学]