CT-1对神经再支配骨骼肌功能恢复的促进作用  

EFFECT OF CARDIOTROPHIN-1 ON FUNCTIONAL RECOVERY OF THE REINNERVATION TO SKELETAL MUSCLE

作　　者：马学晓[1] 张高孟[2] 于腾波[1] 冯勇[2] 顾玉东[2] 

机构地区：[1]青岛大学医学院附属医院骨科,山东青岛266003 [2]复旦大学附属华山医院

出　　处：《青岛大学医学院学报》2008年第6期505-507,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：国家自然科学基金资助项目(30170964)

摘　　要：目的探讨经心脏营养素-1（CT-1）治疗后的失神经骨骼肌重获神经支配后的功能恢复情况。方法60只Swiss小鼠,切断右侧胫神经,随机分成2组,其中一组每天注射外源性CT-1（100μg/kg）,另外一组注射等量CT-1溶媒,1个月后修复胫神经。分别于4、8和12周后检测再生胫神经的有髓神经纤维数、神经再支配骨骼肌的复合肌肉动作电位（CMAP）和肌张力,并与对照组比较。结果与对照组相比,CT-1注射组的再生神经有髓神经纤维数、重获神经支配后的骨骼肌的CMAP和肌张力均有显著提高（t′=6.39-43.36,P〈0.01）。结论CT-1具有促进神经再生和改善骨骼肌收缩功能的双重作用,有效促进了神经再支配骨骼肌的功能恢复。Objective To investigate the function of reinnervated skeletal muscle treated with Cardiotrophin 1 （CT-1）. Methods Sixty Swiss mice with cut-off right tibial nerve were evenly randomized to two groups： 30 mice were intraperitoneally injected exogenous CT-1 （100 μg/kg BW） for one month; others were injected the same amount of CT-1 solvent as control group. One month later, the tibial nerves were repaired. The numbers of myelinated nerve fibres of repaired nerve, the CMAP, latency and tension of reinnervation skeleton muscle were assayed on week 4, 8 and 12. Results Compared with those of the control, the numbers of regenerated myelinated nerve fibres of the nerve, CMAP and tension of reinnervated gastroenemius muscle of the experiment were significantly increased （t＇=6.39--43.36,P〈0.01）. Conclusion CT-1 has dual effects of promoting nerve regeneration and improving the muscle contractile function.

关 键 词：心脏营养素-1 去神经支配 肌 骨骼 功能恢复 

分 类 号：R651.3[医药卫生—外科学] R746.4[医药卫生—临床医学]