促甲状腺激素受体抗体检测甲亢的临床评价(附103例报告)  

Clinical Assessment of Detection of Serum Thyrotropin - Receptor Antibodies or Patients with Hyperthyroidism: Report of 103 Cases

作　　者：欧阳诚[1] 张福芝 

机构地区：[1]中国人民解放军第175中心医院同位素室,漳州363000

出　　处：《标记免疫分析与临床》1997年第4期195-198,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：本文报告检测103例甲亢（其中未治愈组61例，已治愈或缓解组42例）和54名正常人（对照）的血清促甲状腺激素受体抗体（TRAb）的结果。结果表明，未治愈组病人的TRAb值显著地比正常对照组为高（P＜0．001），其中超过最高正常值（14．3U／L）者占73．8％。正常人和其它6种甲状腺疾病无1例超过此值（P＞0．05）；但是ATD治疗缓解者的TRAb值有波动现象，而应用小剂量131I和“散瘿祛亢”汤辩证加减的治愈者则无。我们认为，TRAb值检测为甲亢的诊断和监护提供了一个极好的生化标志物。The values of serum thyrotropin - receptor antibodies (TRAb)of 103 patients with hyperthyroidism and that of 54 healthy peoples were measured. The results showed that the value of serum TRAb of 61 uncured patients with hyperthyroidism was notably higher than that of the control group (P < 0. 001 ), and in 73. 8 % of them it was higher than the maximum normal limit. No significant differences of serum TRAb level were observed among cured or 42 mitigated cases with hyperthyroidism. In other kinds of thyroid diseases and the control group (P >0. 05), none outstriped 14. 3U/L; but the values of TRAb in mitigated patients treated by ATD were fluctuant, while it wasn' t like that in the cases treated by the small dose of radionuclide 131I combinning with 'San Ying on Kang' dicoction with minor modification. We think that the detection of serum TRAb value can provide an excellent biochemical marker for diagnosis and monitor of hyperthyroidism.

关 键 词：甲状腺机能亢进 促甲状腺激素 受体 抗体 

分 类 号：R581.104[医药卫生—内分泌]