中国三城市麻疹母婴配对及小月龄母传抗体水平消长研究  

Levels of transition on maternal transferred measles antibody in infants in 3 cities in China

作　　者：许国章[1] 马瑞[1] 徐宏杰[2] 马衍辉[3] 董红军[1] 李岩[2] 胡风霞[3] 倪红霞[1] 边国林[1] 梁英[2] 刘岚铮[3] 周绍英[1] 怀清杰[2] 韩秀云[3] 

机构地区：[1]宁波市疾病预防控制中心,315010 [2]哈尔滨市疾病预防控制中心 [3]济南市疾病预防控制中心

出　　处：《中华流行病学杂志》2008年第11期1074-1077,共4页Chinese Journal of Epidemiology

基　　金：联合国儿童基金会资助项目

摘　　要：目的了解宁波市、哈尔滨市和济南市小月龄婴儿麻疹年龄构成变化及母传抗体衰减情况。方法收集2004-2007年麻疹疫情资料并分析；同时采用血清流行病学方法进行麻疹母传抗体研究。结果三城市麻疹病例主要发生在〈1岁婴儿中，且〈1岁组麻疹年龄发病率最高；三城市婴儿麻疹病例构成中均以5～8月龄为主。婴儿出生时麻疹抗体阳性率为89．3％，几何平均滴度倒数（GMRT）为738．93；6月龄和8月龄抗体阳性率分别只有6．9％和6．7％，GMRT分别为6．89和3．69；0～8月龄婴儿麻疹抗体阳性率随着月龄的增长呈趋势性下降；母亲的抗体阳性率为84．3％，GMRT为516．94，母亲麻疹抗体主要以低、中水平为主，分别占50．4％和30．3％；母婴麻疹抗体相关系数为0．840。结论麻疹母传抗体下降，6月龄和8月龄婴儿抗体阳性率较低，几乎无保护作用。Objective To understand the epidemiological characteristics of age distribution of measles and related policies on measles vaccines （live; MV） in infants through analyzing the antibody levels of comparison in maternal-infant pairs. Transition of immunity in infants was also studied to provide theoretic basis for measles immunization strategy and to reduce the incidence of month-old infants. Methods In cities of Ningbo, Harbin, and Jinan from Zhejiang, Heilongjiang and Shandong provinces, data was collected from 2004 to 2007 and analyzed regarding the epidemic situation of measles. Studies on maternal- transferred measles antibody were carried our sero-epidemiologically. Results Most of the measles cases were found among babies younger than 12 months, and the incidence of 〈 1 year olds had been increasing. The distribution was dominated by 5-8 month olds in infant measles cases. The positive rate and GRMT of measles antibody in newborns were 89.3 percent and 738.93. The positive rate of the measles antibody and GMRT of the 6-month infant were 6.9 % and 6.89, while 6.7 % and 3.69 in 8-month infant. There was a declining trend of the positive rate of the measles antibody during the newborns to 8-month infant. The positive rate and GRMT of measles antibody in mothers were 84.3 percent and 516.94. Mother＇s measles antibodies mainly to be at low and moderate level, which accounted for 50.4 percent and 30.3 percent respectively, the correlation coefficient between mother and infant was 0. 840. Conclusion Maternal- transferred measles antibody decreased as the growth of infants. The positive rates of measles antibody were quite low in 6-month and 8-month olds which were the age range that needs most attention.

关 键 词：麻疹 婴儿 流行特征 母传抗体 

分 类 号：R511.1[医药卫生—内科学]