隐孢子虫感染动物模型研究进展  

Progress on Animal Model for Cryptosporidium Infection

作　　者：于丽萍[1] 李培英[1] 邱学斌[2] 

机构地区：[1]安徽农业大学动物医学系,安徽合肥230036 [2]安徽省公安厅警犬基地。安徽合肥230061

出　　处：《动物医学进展》2008年第11期67-70,共4页Progress In Veterinary Medicine

基　　金：安徽省自然科学基金项目(070411018)

摘　　要：隐孢子虫病可致人和多种动物的腹泻等症状,是一种人兽共患原虫病,给人类生命安全带来严重威胁,也给畜牧业带来巨大的损失。建立隐孢子虫的感染动物模型对研究隐孢子虫致病机理、免疫及筛选有效的治疗药物等均具有重要意义。文章就隐孢子虫卵囊的分离与纯化、试验用动物的选择、动物模型的建立方法及影响因素等研究做一综述,介绍了隐孢子虫感染动物模型的研究现状,并对该技术的发展前景进行了分析展望。Cryptosporidia are intracellular extracytoplasmatic protozoa with a monoxenous life cycle. They cause a pronounced diarrheal disease and may be life-threatening to humans and animals resulting in consid- erable economic losses in livestock. The establishment of an animal model with Cryptosporidiurn can help to find effective measures for treatment and control of cryptosporidiosis. This article reviewed on the isolation and purification of oocysts, the choice of laboratory animals, animal model approach and impact factors etc. In the present review,the development of infective animal model was introduced,and the prospects were ananlyzed.

关 键 词：隐孢子虫 免疫抑制 感染动物模型 

分 类 号：S852.723[农业科学—基础兽医学]