阿仑磷酸盐治疗老年性OA患者临床研究  

Clinic Study of Biphosphonic Treated Patients with Osteoporsis

作　　者：陈亚萍[1] 周红霞[1] 石国勋[1] 

机构地区：[1]江苏南京医科大学附属无锡第二医院老年科,无锡214002

出　　处：《中国医药导刊》2008年第7期1047-1047,1049,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨阿仑磷酸盐在治疗老年性OA患者中的作用及可能机制。方法:用取能X线骨密度仪测定使用阿仑磷酸盐治疗的OA患者前后的骨密度,应用ELISA法检测患者前后血清中护骨素、破骨细胞分化因子(ODF)的水平。结果;应用双磷酸盐治疗的患者骨密度显著高于未使用者和使用前(P<0.05,);血清中OPG/ODF水平,双磷酸盐治疗的患者高于未治疗的患者和治疗前(P<0.05)。结论:双磷酸盐可以提高OA患者的骨密度,并可能通过改变OPG/ODF的水平对骨代谢进行调节的。Objective： To investigate the effect and possible mechanic of biphosphonic treated patients with osteoporsis. Method： Bone mineral density of patients that were treated with biphosphonic or not was detected by dual-energy X-ray absorptiometer. ELISA was used to detect the osteprotegerin and osteoclast differentitation factor in serum. Bone mineral density and osteprotegerin in serum of patients with osteoporsis treated with biphosphonic were camparaed. Results： Bone mineral density of patients treated with biphosphonic was higher than that of patients treated with not and before （P〈0.05）.OPG/ODF in serum of patients treated with biphosphonic was higher than that of patients treated with not and before （P〈0.05）. Conclusions：Biphosphonic can promote bone mineral density of patients with osteoporsis and promote the level of OPG/ODF in serum to adjust the mechanisms of bone.

关 键 词：阿仑磷酸盐 OA 骨密度 骨保护素 

分 类 号：R684.3[医药卫生—骨科学]