脱管散对兔肢体火器伤愈合的影响  

EMPIRICAL STUDY ON THE INFLUENCE OF TUOGUANSAN TO HEALING OF FIREARM INJURY IN RABBIT'S LIMBS

作　　者：王建 葛宝丰[2] 刘兴炎[2] 陈克明[2] 白孟海[2] 宋敏[2] 

机构地区：[1]陕西省咸阳市第二人民医院 [2]中国人民解放军兰州军区兰州总医院,730050

出　　处：《中医正骨》2008年第11期13-14,共2页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：全军"十一五"重点课题编号:06G033

摘　　要：目的:研究脱管散对火器伤愈合的影响。方法:健康新西兰大白兔20只,每只的双后肢配对分为用药组与对照组,95-式冲锋枪致伤造模,分别于致伤后第3、6、9、12天行弹道生物力学测试及羟脯氨酸含量测定,于各时间点处死5只,处死动物病理取材免疫组化染色测定TGF-β含量,对各时间点的弹道可扩张距离、羟脯氨酸含量、TGF-β含量进行配对t检验。结果:用药组弹道炎症反应轻于对照组,弹道收缩程度(等拉力条件下可扩张距离)、弹道周围软组织羟脯氨酸含量、TGF-β含量均较对照组有统计学差异。结论:中药组方脱管散对火器伤有一定的抗炎作用,能够促进弹道周围肉芽组织增生,提高弹道局部羟脯氨酸含量、TGF-β含量,加速愈合,是一种值得推广的弹道干预方法。Objective:To investigate the influence of TUOGUANSAN (TGS,a TCM composition) to healing of firearm injury.Methods:20 cases of healthy New Zealand rabbits were chosen for the experiment and double posterior limbs of each were mated to divide into drug group and control group,models were made by type 95 submachine gun.Test and measurement on vitodynamics and assaying of hydroxyproline for the path were respectively made on 3 days,6 days,9 days and 12 days after injury.5 cases were killed on the pointed times above and content of TGF-βon patho-organization were determined by immunity class and dyeing.On pointed times above,such items as broadened distance and contents of hydroxyproline and TGF-βfor the path were carried out for mated t- analysis.Result:On inflammatory reaction,drug group was infra to control group.There had statistical discrepancy on shrink extent (broadened distance under the same tensile force),contents of hydroxyproline and TGF- βin surrounding soft tissue for the path between drug group and control group.Conclusion:TGS had some anti-inflammatory action on firearm in jury,for it could promote granulation tissue hyperblastosis in surrounding of the path,elevate contents of hydroxyproline and TGF-βin the part of the path and accelerate the wound's union.It should be sreaded.

关 键 词：火器伤治疗 脱管散药效学 TCF-β 羟脯氨酸 实验研究 动物 兔 

分 类 号：R285.5[医药卫生—中药学]