生脉胶囊对慢性心力衰竭大鼠心肌MMP-3与TIMP-1的影响  

Effect of Shengmai capsules on MMP-3&TIMP-1 of cardiac muscle in rats with chronic congestive heart failure

作　　者：邓元江[1] 梁伟雄[2] 刘卫英[3] 程淑意[2] 陈云波[2] 

机构地区：[1]中山大学附属第一医院,广州510080 [2]广州中医药大学DME中心,广州510405 [3]广东药学院附属第一医院,广州510080

出　　处：《中华中医药杂志》2008年第11期1005-1008,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中国博士后科学基金(No.2005038175);教育部高等学校博士学科点基金(No.20050572008);广东省自然科学基金(No.06300042)

摘　　要：目的:探讨生脉胶囊对慢性心力衰竭大鼠基质金属蛋白酶与金属蛋白酶组织抑制因子的影响。方法:将75只雌性大鼠随机分为假手术组、心衰模型组、生脉胶囊组、卡托普利组、生脉胶囊加卡托普利组,采用腹主动脉缩窄法造成大鼠慢性心力衰竭模型,治疗7周时进行心肌基质金属蛋白酶-3(MMP-3)和金属蛋白酶组织抑制因子-1(TIMP-1)的检测。结果:①心衰模型组心肌MMP-3的含量高于假手术组(P<0.05),生脉胶囊组、卡托普利组、生脉胶囊加卡托普利组MMP-3的含量均低于心衰模型组(P<0.05);②心衰模型组心肌TIMP-1的含量低于假手术组(P<0.05),生脉胶囊组、生脉胶囊加卡托普利组分别高于心衰模型组(P<0.05或P<0.01),且生脉胶囊加卡托普利组高于卡托普利组(P<0.05)。结论:生脉胶囊可降低慢性心衰大鼠心肌MMP-3的含量,提高心肌TIMP-1含量,抑制心肌胶原的过度降解,能阻止心腔的扩大,与减轻慢性心衰心室重构有关。Objective： To research the effect of Shengmai capsules on the matrix metalloproteinase（MMPs） ＆ tissue inhibitor of metalloproteinase（TIMPs） in chronic congestive heart failure（CHF） rats. Methods：75 SD female rats were divided randomly into 5 groups： sham-operation group（A）, CHF model group（B）, CHF model treated by Shengmai capsules group（Shengmai capsule group, C）, CHF model treated by Captopril group（Captopril group, D）, CHF model treated by Shengmai capsule and Captopril group（shengmai capsule ＆ captopril group, E） ,15 rats each group. Suprarenal abdominal artery constriction was operated to prepare CHF rat models. After 7 week treating respectively, the contents of MMP-3 ＆ TIMP-1 of cardiac muscle in rats were detected. Results： The content of cardiac MMP-3 was higher in group B than in group A （P〈0.05） while all lower in group C, D, E than in group B （P〈0.05）. Cardiac TIMP-1 was lower in group B against group A while respectively higher in group C and E than in group B （P〈0.05 or P〈0.01） and the same in group E than in group D （P〈0.05）.Conclusion： Shengmai capsules can keep down the concentration of MMP-3 in myocardium, of rats with CHF elevate the MMP-1, control over-degradation of myocardial collagen and prevent ventricle expanding which was related to relieving the ventricular remodeling of CHF.

关 键 词：心力衰竭 基质金属蛋白酶 金属蛋白酶组织抑制因子 心室重构 生脉胶囊 

分 类 号：R285.5[医药卫生—中药学]