磁流体材料在肿瘤靶向药物传递的应用研究  

Research on Application of Magnetic Fluid Materials in Tumor Target Drug Delivery

作　　者：曹东[1] 易珺[2] 曹晖[3] 袁世英[3] 

机构地区：[1]广州中医药大学信息技术学院,广州510006 [2]广东药学院医药信息工程学院,广州510006 [3]华东交通大学电气与电子工程学院,南昌330013

出　　处：《材料导报》2008年第11期51-53,共3页Materials Reports

基　　金：中国博士后科学基金(2005037279);广东省自然科学基金(06025670)

摘　　要：磁流体以其独有特性在磁靶向药物传递系统中具有较大优势,通过分析磁流体靶向药物传递载体、传递机理研究现状,指出磁流体靶向药物传递主要表现为磁场力与血液流动剪切力之间的竞争。鉴于实验研究中使用的磁场大大超过临床上使用的安全磁场并会对病人造成伤害,提出采用包括恒定磁场和梯度磁场的组合磁场来降低最大磁场强度的思路,并指出磁流体传递过程中需考虑磁流体磁粘特性,以最终降低磁场强度,减少对人体危害,推动临床应用的发展。Based on the magnetic fluid＇s unique properties, it has great advantages in the magnetic target drug delivery system （MTDDS）. Through analyzing the recent research status of magnetic fluid drug delivery carrier and delivery mechanism, the mechanism of the magnetic force versus blood flow shear force is studied. The magnetic field intensity adopted in experiment is bigger than the safe magnetic field intensity used in clinic and will harm to patients. The method of combined magnetic filed including one constant magnetic filed and one gradient magnetic field is pointed out to reduce the maximum magnetic field intensity. The magnetoviseous property of magnetic fluid should also be considered in MTDDS delivery process to finally reduce the magnetic field intensity and harm to patients and improve the development of MTDDS in clinic application.

关 键 词：磁流体 靶向药物传递 肿瘤 

分 类 号：TQ464.7[化学工程—制药化工] TQ658