宫颈粘液葡萄糖果糖水平与不明原因不孕关系的探讨  

Study of the relationship between the concentration of fructose and glucose in human cervical mucus and unexplained infertility

作　　者：阮祥燕[1,2] 曹缵孙[1,2] 毛文军[1,2] 李广元[1,2] 高艳萍[1,2] 

机构地区：[1]华西医科大学 [2]西安医科大学附属第一医院妇产科生殖内分泌研究室

出　　处：《生殖医学杂志》1997年第2期108-111,共4页Journal of Reproductive Medicine

摘　　要：对２３例不明原因不孕患者的２３个月经周期及对照组１５名健康妇女２０个月经周期的宫颈粘液葡萄糖果糖水平进行测定，并以放射免疫法测定血清黄体生成素（ＬＨ）、卵泡刺激素（ＦＳＨ）、雌二醇和孕酮；阴道Ｂ超监测卵泡发育；宫颈粘液改良Ｉｎｓｌｅｒ评分、尿ＬＨ酶联免疫测定和基础体温测定综合评价预测和确定排卵日，于围排卵期进行性交后试验（ＰＣＴ）。结果：４３个月经周期均为有排卵周期。不孕组包括ＰＣＴ正常组７周期及ＰＣＴ异常组１６周期的宫颈粘液改良Ｉｎｓｌｅｒ评分与对照组无显著差异（Ｐ均＞０．０５）；不孕组中ＰＣＴ异常组卵泡期、排卵前、后及黄体期宫颈粘液葡萄糖果糖水平均明显低于对照组（Ｐ＜０．０１），而ＰＣＴ正常组与对照组无明显差异（Ｐ＞０．０５）。认为：宫颈粘液葡萄糖果糖水平低落可影响精子的穿透和存活，是不明原因性不孕的重要因素之一，Objective: To explain the relationship between carbohydrates in cervical mucus and unexplained infertility. Design: Prospective controlled study. Setting:The outpatient Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Medical University. Methods: Follicle stimulating hormone(FSH),estradiol(E 2)and progestrone(P) in blood samples and cervical mucus were measured by RIA.The glucose and fructose concentration in cervical mucus were determined by using the methods of enzmyes of glucose oxidaseperoxidase and resorcinol oxidation, respectively. Vaginal ultrasonic monitoring and postcoital test(PCT) were applied. Patients were divided into two groups(abnormal,normal),based on the results of PCT. Results: In PCT abnormal group, the concentration of glucose and fructose in cervical mucus were lower significantly than that of in the control group( P <0.05) Conclusion: The lower concentration of glucose and fructose in human cervical mucus may influence the sperm penetration activity and its survival time in cervical mucus. This may play an important role in unexplained infertility.

关 键 词：女性不育 子宫颈粘液 葡萄糖 果糖 

分 类 号：R711.602[医药卫生—妇产科学]