高尿酸血症与新发颈动脉粥样硬化斑块的关系  

The association between hyperuricemia and prevalence of carotid plaque

作　　者：李岩[1] 赵冬[1] 刘静[1] 李治安[2] 勇强[2] 王薇[1] 

机构地区：[1]首都医科大学附属北京安贞医院 北京心肺血管疾病研究所流行病研究室,北京100029 [2]首都医科大学附属北京安贞医院超声科,北京100029

出　　处：《中华内科杂志》2008年第11期906-909,共4页Chinese Journal of Internal Medicine

基　　金：基金项目：“八五”国家科技攻关计划（85-915-01-02）;国家科技支撑计划（2006BA101A02）;北京高技术文验室计划（953850700）

摘　　要：目的通过分析人群高尿酸血症与颈动脉斑块发生的关系，探讨血清尿酸在动脉粥样硬化疾病早期预防中的价值。方法研究对象是中国多省市心血管病研究（CMCS）中的一部分，2002年对1442人进行危险因素调查和颈动脉超声检查，2007年进行第二次颈动脉超声检查，本研究对两次资料完整且基线无颈动脉斑块的810人进行分析。结果（1）基线高尿酸血症患病率年龄标化后为5．4％，男性7．7％，女性3．9％；（2）5年间颈动脉斑块发病率年龄标化后为45．3％，男性51．7％，女性42．7％，颈总动脉分叉处斑块发病率在四个测量部位中最高；（3）调整年龄、吸烟、高TC、高TG、高血压、糖尿病、超重和肥胖等因素，女性高尿酸血症是颈总动脉分叉处新发斑块的独立的危险凶素，OR为3．56（P=0．02，95％CI=1．21～10．41）。结论高尿酸血症对女性颈总动脉分叉处斑块发生有独立的预测作用，对男性颈动脉斑块形成无独立的影响作用；Objective To analyze the association of hyperuricemia with incidence of carotid plaque in general population and furthermore to explore the predictive value of serum uric acid in the early prevention of atheroselerotic disease. Methods The participants were selected from a part of Chinese Multiprovincial Cohort Study （CMCS）. Two investigations on cardiovascular risk factors and two on carotid ultrasound detection were carried out in 2002 and 2007, respectively. Results （1） The standard prevalence of hyperufieemia on baseline was 5.4% , being 7.7% in male and 3.9% in female. （2） The standard incidence of carotid plaque was 45.3% , being 51.7% in male and 42. 7% in female. It was shown that the incidence of plaque in the bulb of common carotid arteries was the highest. （3） After adjusting for age, smoking, high triglyeeride, high cholesterol, hypertension, diabetes, overweight and obesity, hyperurieemia in female was an independent risk factor associated with 5-year incidence of formation plaque in the bulb of common carotid; the odds ratio （OR） was 3.56 （P =0.02, 95%CI = 1.21-10.41）. Conclusion Hyperurieemia in female was an independent risk factor associated with 5-year incidence of plaque formation in the bulb of common carotid, and hyperuficemia in male was not an independent factor associated with 5-year incidence plaque formation.

关 键 词：尿酸 冠状动脉硬化 颈动脉疾病 队列研究 

分 类 号：R686[医药卫生—骨科学]