系统性红斑狼疮患儿PD-1分子的表达  

Expression of PD-1 on peripheral blood lymphocyte in systemic lupus erythematosus patients

作　　者：夏敏[1] 薛海燕[1] 曹兰芳[1] 

机构地区：[1]上海交通大学医学院附属仁济医院儿科,上海200001

出　　处：《临床儿科杂志》2008年第11期959-961,共3页Journal of Clinical Pediatrics

基　　金：上海市科学技术委员会科研计划项目(No.044119716)

摘　　要：目的研究PD-1分子的表达与系统性红斑狼疮(SLE)的发病机制及病情的关系。方法应用流式细胞仪检测各期SLE患儿(活动期、缓解期)外周血CD3+、CD4+、CD8+T细胞上PD-1分子的表达。结果在各期SLE患儿中外周血CD3+、CD4+、CD8+淋巴细胞上PD-1分子的表达均明显高于正常对照(P<0.05)。结论在系统性红斑狼疮患儿外周血淋巴细胞上PD-1分子表达明显高于正常,各组SLE患儿存在B淋巴细胞的异常增殖,推测PD-1通路在SLE的免疫病理中发挥重要作用。Objectives To investigate the role of PD-1 in pathogenesis of patients with systemic lupus erythematosus （SLE） . Methods Flow cytometjry was used to determine expression of PD-1 on peripheral blood lymphocyte in SLE patients （include active stage group and catabasis group）. Results Expression of PD-1 on peripheral blood lymphocyte in both SLE patient groups are significantly higher than that in health control （P 〈 0.05）. Conclusions Expression of PD-1 on peripheral blood lymphocyte in SLE patients are obviously higher than that in health control, and B cells abnormally generate in SLE children. We asume that PD-1 pathway may play an important role in immunopathogenesis of SLE patients.

关 键 词：PD-1分子 系统性红斑狼疮 儿童 

分 类 号：R725.9[医药卫生—儿科]