动脉粥样硬化患者血浆apelin水平的变化  

Plasma apelin concentration in patients with atherosclerosis

作　　者：王大为[1] 付研[1] 张立克[2] 唐朝枢[3] 

机构地区：[1]首都医科大学附属北京同仁医院经济开发区院区综合内科,北京市100730 [2]首都医科大学病理生理教研室 [3]北京大学医学部生理学与病理生理学系

出　　处：《中华老年多器官疾病杂志》2008年第5期376-378,382,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的研究动脉粥样硬化患者血浆apelin水平的变化,并探讨apelin与动脉粥样硬化的关系及可能的影响因素。方法选择动脉粥样硬化患者40例,非动脉粥样硬化对照者30例,用放射免疫法测定两组血浆apelin的水平,并测定两组体重指数(BMI)、腰臀比(WHR)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)等指标并进行分析。结果动脉粥样硬化组血浆apelin水平明显高于非动脉粥样硬化对照组,两组间BMI、WHR、TC、LDL有显著性差异。血浆apelin水平与BMI、WHR呈正相关。结论动脉粥样硬化患者血浆apelin水平升高,并与BMI及WHR呈正相关,提示apelin可能参与肥胖相关的动脉粥样硬化的病理生理过程。Objective To study the change of plasma apelin in patients with atherosclerosis and its relationship with atherosclerosis, and to analyse the possible relative factors. Methods Forty patients with atherosclerosis and other 30 patients without atherosclerosis as the control were enrolled. The concentration of plasma apelin was meas- ured with radioimmunoassay. Body mass index（BMI）, waist-hip ratio （WHR）, triglyceride（TG）, total cholesterol （TC）,low density lipoprotein （LDL）, high density lipoprotein （HDL）were measured and analysed. Results The plasma apelin level of the group with atherosclerosis was significantly higher than that of the control group without atherosclerosis, the differences in BMI,WHR, TC, LDL of two groups were statistically significant. The plasma apelin concentration was positively correlated with BMI and WHR. Conclusion Plasma apelin concentration is increased in the patients with atherosclerosis,and positively correlates with BMI and WHR. Apelin might be involved in the pathogenesis of obesity-related atherosclerosis.

关 键 词：动脉粥样硬化 APELIN 患者 临床分析 

分 类 号：R543.5[医药卫生—心血管疾病] R341.2[医药卫生—内科学]