老年男性慢性躯体疾病合并抑郁患者新生肿瘤和死亡的随访研究  

New tumor morbidity and mortality in male elderly depressive patients with chronic somatic diseases

作　　者：冯杰[1] 郎森阳[1] 宋克群[2] 杨君[1] 赵志勇[1] 刘克新[3] 

机构地区：[1]解放军总医院医学心理科,北京市100853 [2]解放军总医院干部诊疗科,北京市100853 [3]解放军总医院病案科,北京市100853

出　　处：《中华老年多器官疾病杂志》2008年第5期392-394,共3页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：解放军总医院院长基金资助项目(06LN11)

摘　　要：目的探讨伴有抑郁情绪的老年男性慢性躯体疾病与新生肿瘤和死亡的相关性。方法在前期以老年抑郁量表和一般生活资料调查表对1020例老年男性进行研究的基础上,通过3年的随访,分析合并抑郁人群与非抑郁人群新生肿瘤的发生率及死亡率。结果老年男性慢性躯体疾病合并抑郁人群新生肿瘤的发生率OR=2.163 (95%CI 1.394～3.357),危险程度明显高于非抑郁人群,差异有统计学意义;抑郁人群风险明显高于非抑郁人群(OR=5.207,95%CI 2.487～10.902),差异有统计学意义。经Logistic多元线性回归分析,结果显示,是否抑郁和抑郁的严重程度分别与新生肿瘤率和死亡率成正相关。结论老年男性慢性躯体疾病合并抑郁的患者易发新生肿瘤,且死亡率明显高于同组疾病人群未合并抑郁者。Objective To investigate the new tumor morbidity and mortality in male elderly depressive patients with chronic somatic diseases by a three-year follow-up. Methods A total of 1020 male elderly patients with chronic somatic diseases were investigated by questionnaire of the Geriatric Depression Scale in 2003. Through three years of follow-up the new tumor morbidity and mortality in depressive group and non-depressive group were analyzed. Re- sults The new tumor morbidity and mortality were significantly higher in the depressive male elderly patients with chronic somatic diseases than those in the patients without depression, OR= 2. 163 （95%CI 1. 394--3. 357） and OR= 5. 207 （95%CI 2. 487--10. 902）, respectively. Multivariate Logistic regression analysis showed that the comorbidity of patients with depression and the depression degree were positively correlated with new tumor morbidity and mortality respectively. Conclusion The depressive male elderly patients with chronic somatic diseases were more lia- ble to have new tumor and higher morbidity and mortality than those without depression.

关 键 词：老年人 男性 抑郁 肿瘤 死亡率 

分 类 号：R592[医药卫生—老年医学] R749[医药卫生—内科学]