血液灌流治疗尿毒症的临床观察  

The clinical study of hemoperfusion in chronic uremia

作　　者：王峥嵘[1] 李军辉[1] 

机构地区：[1]河南省商丘市第一人民医院肾内科,476100

出　　处：《中国临床实用医学》2008年第11期13-14,共2页China Clinical Practical Medicine

摘　　要：目的探讨血液灌流治疗尿毒症患者的疗效与安全性。方法维持性血液透析患者31例，采用血液灌流／血液透析（HP／HD）联合治疗方法与常规血液透析（HD）方法对比（自身对比）。治疗前后检测中分子物质（MMS）、血尿素、肌酐、白蛋白、血细胞及临床症状。结果血液灌流能显著清除尿毒症患者体内的中分子物质，单次使用治疗2h MMS平均下降25．0％，最高达44．4％。而普通透析对MMS无多大影响，两者具有显著性差异（P〈0．001）。同时患者的睡眠、食欲、皮肤瘙痒有不同程度的改善，未发生其他任何不良事件和不良反应。结论作为中分子物质的清除治疗措施，血液灌流临床使用安全、疗效可靠，无毒副反用。Objective To investigate the effect and safety of hemoperfusion in uremia. Methods Thirty-one uremia patients were treated with combined hemodialysis resin hemoperfusion. Middle molecular substances （ MMS）, urea , creatinine, albumin, blood cells were detected before and after the treatment. Results MMS was reduced significantly in combined hemodialysis hemoperfusion procedure （P〈0.001）. With conventional hemodialysis, a combination of hemoperfusion and bemodialysis had a better effect in MMS clearance （P〈0.001）. Meanwhile, some clinical conditions （ appetite, pruritus, insomnia） improved. We did not find any adverse effect. Conclusion Resin hemoperfusion can effectively clean MMS and was confirmed to be a safe and risk free procedure.

关 键 词：血液灌流 血液透析 尿毒症 中分子毒素 

分 类 号：R692.5[医药卫生—泌尿科学]