联苯双酯引起肝损害加重  

Aggravated liver damage attributed to bifendate

作　　者：吴淑云[1] 侯志文[1] 李岩[1] 

机构地区：[1]北京地坛医院门诊,北京100011

出　　处：《药物不良反应杂志》2008年第5期363-363,共1页Adverse Drug Reactions Journal

摘　　要：1例30岁妊娠女性,因慢性乙型肝炎入院。经保肝药物治疗,患者肝功能好转。为进一步降低氨基转移酶水平,加用联苯双酯15mg,3次/d治疗。2周后,患者肝功能恶化。实验室检测示:ALT24.9U/L,AST328.9U/L,TBil32.0μmol/L,DBil20μmol/L。停用联苯双酯,其他保肝药物继续使用,患者肝功能恢复正常。A 30-year-old pregnant woman was hospitalized with chronic hepatitis B. After treatment with liver-protective medications, her liver function improved. In order to reduce transaminase levels further, bifendate 15 mg thrice daily was added to her regimen. Two weeks later, her liver function worsened. Laboratory- investigations revealed the following： ALT 24.9 U/L, AST 328.9 U/L,TBil 32.0 μmol/L, DBil 20μmol/L. The bifendate was stopped, and other liver-protective medications were continued. Her liver function returned to normal limits.

关 键 词：联苯双酯 肝损害加重 不良反应 

分 类 号：R595.3[医药卫生—内科学]