替硝唑片剂在维吾尔族和汉族健康人体的药代动力学研究  

Pharmacokinetic of tinidazole tablet in Uigur and Han healthy volunteers

作　　者：郭涛[1] 常馨予[2] 夏东亚[1] 曾平[3] 地里夏提·白克力[3] 刘璟[3] 

机构地区：[1]沈阳军区总医院药剂科,辽宁沈阳110016 [2]沈阳药科大学药学院,辽宁沈阳110015 [3]兰州军区乌鲁木齐总医院药剂科,新疆乌鲁木齐830000

出　　处：《中国药理学通报》2008年第11期1482-1485,共4页Chinese Pharmacological Bulletin

基　　金：全军医学科学技术研究“十一五”计划科技攻关课题基金资助项目(No06G023)

摘　　要：目的研究维吾尔族和汉族健康志愿者单剂量口服替硝唑片的药代动力学。方法健康志愿者20名(其中维吾尔族10名,汉族10名,男女各半),单剂量口服替硝唑片剂1g;采用高相液相色谱法测定血浆中替硝唑的含量;用DAS软件程序进行数据处理并采用SPSS软件进行统计学分析。结果维吾尔族受试者单剂量口服1g替硝唑片剂的主要药动学参数为:Cmax为(18.81±3.10)mg·mL-1,Tmax为(2.25±0.54)h,T12为(14.34±1.92)h,AUC0～72h为(378.40±40.56)mg.h.L-1。汉族受试者的主要药动学参数:Cmax为(19.04±2.42)mg·mL-1,Tmax为(2.15±0.47)h,T21为(16.94±2.40)h,AUC0～72h为(454.37±59.74)mg.h.L-1。结论替硝唑片剂在维吾尔族和汉族健康志愿者体内药动学参数差异有显著性,性别间药动学参数差异有显著性。Aim To study the pharmacokinetics of tinidazole tablet after a single oral dose in Uigur and Han healthy volunteers. Methods Twenty volunteers were involved in the study, including ten Uigur volunteers and ten Han volunteers. Each subject received a single dose of 1 g tinidazole tablet. The plasma concentration was determined by HPLC. The pharmacokinetic param- eters were calculated by DAS software and compared by SPSS software. Results The main pharmacokinetic parameters of Uigur were as follows：Cmax was （18. 81 ±3. 10） mg · L6-1 ,Tmax was （2.25 ±0. 54） h,T1/2 was（14.34 ± 1.92） h, AUC0-72h was （484. 74 ±58.20） mg · h · L^-1. The main pharmacokinetics parameters of Han were as follows：Cmax was （ 19.04 ±2.42） mg· L^-1,Tmax was （2. 15 ±0.47） h, T1/2was （16.94 ± 2 2.40） h,AUC0-72hwas （378.40 ±40.56） mg· h · L^-1. Conclusions The results showed that the main pharmacokinetie parameters of tinidazole had significant differences between Uigur and Han, and had significant differences between males and females.

关 键 词：替硝唑 高效液相色谱法 维吾尔、汉民族 药代动力学 

分 类 号：R446.11[医药卫生—诊断学] R452[医药卫生—临床医学]