黄连吴茱萸药对配伍变化对黄连生物碱煎出及其对大鼠小肠吸收的影响  

Influence on rat intestinal absorption of huanglian alkalis after match-pair of huanglian-wuzhuyu

作　　者：孙万晶[1] 张玉杰[1] 姚南[2] 姜昊[1] 汪祺[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]兰州大学第一医院,甘肃兰州730000

出　　处：《中国中药杂志》2008年第22期2614-2616,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30672585)

摘　　要：目的:研究吴茱萸对黄连生物碱成分煎出和的大鼠小肠吸收的影响,探讨黄连吴茱萸药对配伍的机理。方法:以HPLC测定黄连生物碱成分含量,采用大鼠非翻转肠囊实验和翻转肠囊实验,考察吴茱萸对黄连生物碱小肠吸收和转运的影响。结果:随吴茱萸配伍比例的增加黄连煎液中生物碱成分含量呈下降的趋势,黄连配伍吴茱萸后可使小肠吸收黄连生物碱作用得到改善,当黄连与吴茱萸配比为6∶1时,黄连生物碱成分的小肠吸收最为明显。结论:黄连吴茱萸配比为6∶1时,吴茱萸促进黄连生物碱的小肠吸收最强,小肠吸收是黄连吴茱萸配伍作用的重要环节。Objective： To research effect of Wuzhuyu on Huanglian intestinal absorption and to provide some basic principle of match-pair of huanglian-rougui. Method： The rat everted gut sac method as well as non everted gut sac method was applied to investigate the influence of Wuzhuyu on Huanglian intestinal absorption. Result： The content of each alkalis in Huanglian was decreasing with the comptibale ration increase, and the intestinal absorption had been improved in some degree. The intestinal absorption of Huanglian alkalis reached the highest level when match-pair ration of huang Lian-rougui was 6： 1. Conclusion： The chemical reaction in the progress of extraction and the intestinal absorption of huanglian alkalis were the key factors of match-pair of huanglian-wuzhuyu.

关 键 词：黄连吴茱萸药对配伍 小肠吸收 黄连生物碱 

分 类 号：R284.1[医药卫生—中药学]