瓜蒌薤白汤对平阳霉素所致大鼠肺纤维化肺组织中细胞因子PDGF-BB表达的影响  

Effect of Gualou Xiebai (GLXB) decoction on platelet-derived growth factor BB (PDGF-BB) expression in lungs from bleomycin A5 induced pulmonary fibrosis in rats

作　　者：李瑞琴[1] 肖红[2] 张瑞[1] 李伟[1] 宋建平[1] 

机构地区：[1]河南中医学院,河南郑州450008 [2]河南职工医学院,河南郑州450008

出　　处：《中国中药杂志》2008年第22期2666-2670,共5页China Journal of Chinese Materia Medica

基　　金：河南省教育厅自然科学基金项目(2003360193)

摘　　要：目的:探讨瓜蒌薤白汤防治肺纤维化的作用机制。方法:大鼠随机分为正常组,模型组,瓜蒌薤白汤组,阳性药氢化可的松组。用平阳霉素(3 mg.kg-1)复制大鼠肺纤维化模型后,用药组每天灌胃瓜蒌薤白汤0.02mL.kg-1,氢化可的松组腹腔注射5 mg.kg-1。用药28 d后处死,观察、比较各组大鼠肺组织中血小板源生长因子BB(PDGF-BB)的表达。结果:模型组大鼠肺组织中PDGF-BB表达均明显高于正常组及用药组(P<0.05)。结论:瓜蒌薤白汤能明显抑制肺组织中PDGF-BB过度表达。Objective： To investigate the effect and mechanism of Gualou Xiebai （GLXB） decoction on pulmonary fibrosis. Method： Pulmonary fibrosis was induced by bleomycin A5 in SD rats. Rats in treatment group were killed after being treated by GLXB by decoction daily for 28 days. The lungs of all rats were harvested for histopathological studies. The contents of platelet-derived growth factor BB （PDGF-BB） in lungs were measured and compared. Result： The contents of PDGF-BB in lungs have increased significantly in model group compared with normal group and treatment group （P 〈 0.05 ）. Conclusion： GLXB decoction could significantly alleviate the increased PDGF-BB expression in lungs of pulmonary fibrosis rats.

关 键 词：肺纤维化 血小板源生长因子BB 瓜蒌薤白汤 

分 类 号：R285.5[医药卫生—中药学]