磷脂酶D与病原微生物感染  

Phospholipase D and Pathogenic Microorganisms Invasion

作　　者：李帅[1] 韩雪琳[1] 于仁涛[1] 孙岩松[1] 韩黎[1] 

机构地区：[1]军事医学科学院疾病预防控制所医院感染监督中心,北京100071

出　　处：《微生物学通报》2008年第11期1802-1805,共4页Microbiology China

基　　金：国家自然科学基金资助项目(No.30500462)

摘　　要：磷脂酶D(phospholipase D,PLD)普遍存在于细菌、真菌以及哺乳动物中。在病原微生物中,PLD作为毒力决定因子在减数分裂、孢子形成等过程中起作用;在哺乳动物细胞中,PLD主要在胞膜转运、调节有丝分裂和细胞肌动蛋白骨架等一些信号转导中起作用。在病原菌感染宿主细胞的过程中,病原体和宿主细胞的PLD都被激活并发生级联反应,病原菌PLD可调节自身肌动蛋白丝的聚合和重排,并引起宿主细胞局部肌动蛋白丝的集聚,诱导宿主细胞对其吞噬。深入探讨PLD激活对感染发生的调控作用对透彻理解病原菌感染宿主细胞的分子机制具有重要意义。Phospholipase D（PLD） is ubiquitous in bacteria,fungi,and mammal.In pathogenic microorganisms,PLD can be pathogenic determinant and play a role in spore generation.In mammalian cells,PLD functions in several signal transduction pathways,such as membrane transportation,mitosis regulation,and actin cytoskeleton regulation.In the process of pathogens invasion host cells,both of the pathogen and host cells’ PLD will be activated and a series of cascade reaction will be generated.During this process,pathogen’s PLD can regulate the polymerization and reorganization of its own actin filaments and induce the polymerization or reorganization of the host cell actin filaments near the foci,thus to promote the phagocytosis of the pathogen by host cell.Investigating the role of PLD activation in the infection will be significance for further understanding the molecular mechanism of pathogen-host cell interaction.

关 键 词：磷脂酶D 信号转导 病原微生物 

分 类 号：R37[医药卫生—病原生物学]