鹿瓜多肽注射液联合阿伦膦酸盐治疗绝经后骨质疏松性骨折的临床观察  

Therapeutic effect of cervus and cucumis polypeptide for injection combination with alendronate on postmenopausal osteoporotic fracture

作　　者：邸军[1] 张伟[1] 王燕[1] 支忠继[1] 

机构地区：[1]河北医科大学第三医院,石家庄050051

出　　处：《临床合理用药杂志》2008年第1期2-3,共2页Chinese Journal of Clinical Rational Drug Use

基　　金：河北省科技攻关项目(No.042761555)

摘　　要：目的观察中西医结合治疗绝经后骨质疏松性骨折的有效性。方法选取绝经后老年妇女126例,双能X线骨密度仪(DEXA)确诊为骨质疏松症,X线确诊至少1个部位病理性骨折,手术基础上给予鹿瓜多肽注射液16mg/d,静脉滴注,共15d;同时口服阿伦膦酸钠10mg/d,4周后改为70mg/周,持续20周;对照组采取单纯手术治疗。24周后观察骨密度、骨折愈合、疼痛指数。结果治疗组骨密度明显升高[(0.72±0.09)g/cm2vs(0.62±0.07)g/cm2,P<0.01];四肢骨干骨折治疗组平均愈合时间为(12.4±2.9)周,对照组为(16.4±3.3)周,2组之间有统计学差异(P<0.01);1周内治疗组疼痛程度明显小于对照组(P<0.01),1周后无明显差异(P>0.05)。结论中西药物联合治疗骨质疏松性骨折能够显著改善患者的临床症状,增加骨密度,促进骨折愈合。Objective To observe the effectiveness of integrated the traditional Chinese and western medicine in treating postmenopausal osteoporotic fracture. Methods 126 post - menopausal female were diagnosis osteoporosis by DEXA, and at least one pathological fracture confirmed with X - ray. All cases underwent surgery, eervus and eueumis polypeptide for injection （ 16mg/d, 15d）, oral alendronate 10mg/d, 4 weeks later changed to 70mg/w, 20 weeks; surgery only in control group without medicine therapy. The bone mineral density, fracture healing, pain index were evaluated after 24w treatment. Results In treatment group, bone mineral density [ （0.72 ± 0.09 ） g/cm^2 vs （ 0.62 ± 0.07 ） g/cm^2, P 〈 0. 011 were significantly increased; limbs shaft fractures in the treatment group the average healing time was （12. 4 ± 2. 9 ） weeks; for the control group, （16. 4 ± 3. 3）weeks . There was significant difference between two groups （P 〈 0.01 ）. The pain index was lower in treatment group than control group （ P 〈 0.01 ） within 1 week, but there was no significant difference after lw （ P 〉 0. 05 ）. Conclusion The integrated traditional Chinese and Western medicines could improve the clinical symptoms of osteoporotic fracture, and increase bone density, promoting healing.

关 键 词：鹿瓜多肽注射液 阿伦膦酸钠 骨质疏松性骨折 

分 类 号：R580[医药卫生—内分泌] R683[医药卫生—内科学]