MUC1在子宫内膜的表达及在胚胎着床中的意义  

MUC1 expression in endometrium and effection in embryo implantation

作　　者：项双卫[1] 陈玲[1] 

机构地区：[1]福建医科大学附属协和医院妇产科,福州350001

出　　处：《现代妇产科进展》2008年第10期762-766,共5页Progress in Obstetrics and Gynecology

基　　金：福建省教育厅科研基金资助项目(No:JA03097)

摘　　要：目的:探讨粘蛋白1(MUC1)在子宫内膜中的表达及其与不明原因不孕症的关系。方法:用免疫组化二步法检测43例子宫肌瘤患者子宫内膜、18例正常早孕期蜕膜及20例难免流产早孕期蜕膜MUC1的表达;用免疫组化二步法、原位杂交技术,检测19例不明原因不孕及18例继发性不孕患者分泌中期子宫内膜MUC1、MUC1mRNA的表达。结果:肌瘤组各期均见MUC1表达,且在分泌中期达高峰;早孕组、难免流产组与对照组MUC1表达两两比较差异无统计学意义(P>0.05);不孕组MUC1蛋白及mRNA表达较对照组低,差异有显著统计学意义(P<0.05)。结论:MUC1在子宫内膜中的表达呈周期性变化;MUC1表达异常可能阻碍子宫内膜接受性的形成从而成为不孕的病因之一。Objective：To investigate the expression of MUC1 in endometrium of women and its effeetion in emgryo implantation. Methods： Immunohistoehemical method （ Polymer Detection System） was utilized to determine the location of MUC1;in situ hybridization method was to determine the location of MUC1 mRNA. One hundred and eighteen cases were included ： forty three cases with hysteromyoma, eighteen cases with early pregnancy, twenty women in early pregnancy with inevitable abortion, nineteen patients with unexplained infertility （infertile group） and eighteen patient with secondary infertility（control group）. Results：MUC1 was diffusely distributed in the cytoplasm of luminal and glandular epithelia and expressed in highest level in mid-luteal phase. The expression of MUC1 were in the control group, early pregnant group and inevitable abortion group （ P 〉 0.05 ） ; MUC1 protein and mRNA expression during mid-luteal phase in infertile group was significantly lower than those in control group （P 〈 0.05 ）. Conclusion：MUC1 expressions in endometrium are changed in menstrual cycle. Decreasing expression of MUC1 influences the establishment of endometrial receptivity and may be one of the major causes of unexplained infertility.

关 键 词：粘蛋白类 子宫内膜 不明原因不孕 

分 类 号：R711.6[医药卫生—妇产科学]