胃肠内补液为主治疗糖尿病酮症酸中毒54例临床观察  

Clinical observation on fluid infusion through gastrointestinal tract for treatment of diabetic ketoacidosis

作　　者：徐艳春[1] 

机构地区：[1]临沂市中医医院,山东临沂276002

出　　处：《齐鲁护理杂志》2008年第11期14-15,共2页Journal of Qilu Nursing

摘　　要：目的:探讨胃肠内补液为主治疗糖尿病酮症酸中毒的疗效。方法:将104例糖尿病酮症酸中毒患者随机分为治疗组54例和对照组50例,治疗组以胃肠内补液为主进行治疗,对照组以静脉补液为主进行治疗,观察治疗前后两组患者血生化和尿酮体的变化,并对结果进行统计学分析。结果:治疗24h后两组血糖、血钠、血尿素氮均明显下降(P<0.05,P<0.01);治疗组与对照组相比血钠、血尿素氮降低更明显(P<0.05,P<0.01),二氧化碳结合力恢复正常时间快(P<0.01);治疗组尿酮体消失时间、意识恢复时间均短于对照组(P<0.01);治疗组病死率为1.85%,对照组病死率为8.00%。结论:根据胃肠内补液的特点采取以胃肠内补液为主的方法治疗糖尿病酮症酸中毒,有利于纠正代谢紊乱,预防脑水肿、肺水肿等并发症,简便、安全有效。Objective ： To explore the therapenutic efficacy of fluid infusion through gastrointestinal tract for treatment of diabetic ketoacidosis. Methods： One handred and four patients with diabetic ketoaeidosis were randomly divided into treatment group （ n = 54 ） and control group （ n = 50 ）. Fluid infusion through gastrointestinal tract was given to the patients in treatment group and introvenous infusion was taken in control group. The change of blood biochemical parameters and excretion of urinary ketone bodies in both groups were observed before and after treatment and analyzed statistically. Results ： In the two groups, the blood level of glucose, sodium and BUN decreased in 24 hours after treatment （ P 〈 0. 05, P 〈 0.01 ） , and that of the treatment group decreased obviousely as compared with the control group （ P 〈0. 05, P 〈0. 01）. The blood carbon dioxide combining power returned to normal state more quickly （ P 〈 0. 01 ）. Disappearing time of urinary ketone bodies and the time of consciousness recovery were shorter in treatment group than that in control group （ P 〈 0. 01 ）. The fatality rate of treatment group was 1. 85% and that of control group was 8%. Conclusion： Fluid infusion through gastrointestinal tract can correct metabolism disturbance, prevent incidence of cerebral and pulmonary edema in the treatment of DKA.

关 键 词：糖尿病酮症酸中毒 胃肠内补液 静脉补液 治疗效果 

分 类 号：R473.5[医药卫生—护理学]