N-(5-邻氯苯基-2-呋喃甲酰氨基)丙氨酰胺衍生物的合成和生物活性测定  

Synthesis and Biological Activity of N-[5-(2-Chlorophenyl)furan-2-formylamino]alanamide Derivatives

作　　者：胥杨[1] 薛思佳[1] 孙晋峰[1] 方治坤[1] 尹安琴[1] 陈龙[1] 

机构地区：[1]上海师范大学生命与环境科学学院化学系,上海200234

出　　处：《有机化学》2008年第11期1997-2000,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20672073);上海市重点学科建设(No.T0402)资助项目.

摘　　要：以5-邻氯苯基-2-呋喃甲酰氯和丙氨酸为起始原料,通过非均相法得到N-(5-邻氯苯基-2-呋喃甲酰氨基)丙氨酸,再与10种不同取代苯胺反应,通过N,N'-二环己基碳二亚胺和4-二甲氨基吡啶(DCC/DMAP)偶合法设计合成了10个未见文献报道的N-(5-邻氯苯基-2-呋喃甲酰氨基)丙氨酰胺类衍生物4a～4j.通过元素分析,1HNMR,IR和MS确定化合物的结构,初步生物活性测试表明标题化合物具有一定的除草活性.N-[5-（2-Chlorophenyl）furfuroyl]alanine was prepared by taking 5-（2-chlorophenyl）furfuroyl chloride and alanine as raw materials via a nonhomogeneous reaction. Ten unreported N-[5-（2-chloro- phenyl）furan-2-formylamino]alanamide derivatives （4a-4j） were designed and synthesized by using a DCC/DMAP coupling method with N-[5-（2-chlorophenyl）furfuroyl]alanine and 10 differently substituted anilines. The structures of the target compounds were confirmed by MS, IR, ^1H NMR spectra, and elemental analysis. The preliminary biological tests show that some of the target compounds have certain herbicidal activities.

关 键 词：丙氨酸 5-邻氯苯基-2-呋喃甲酰氯 酰胺 衍生物合成 除草活性 

分 类 号：TQ450.2[化学工程—农药化工]