益肝饮治疗慢性丙型肝炎的临床研究  

Clinical Study on Chronic Hepatitis C Treated with Yigan Yin

作　　者：牛桂玲 买桂芳 李志兰 

机构地区：[1]宁夏海原县人民医院内科,宁夏海原755200

出　　处：《辽宁中医杂志》2008年第11期1679-1680,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:观察益肝饮治疗慢性丙型肝炎的临床疗效。方法:选择慢性丙型肝炎40例,随机分为益肝饮治疗组20例和干扰素α-2b联合利巴韦林对照组20例,疗程均为半年,观察治疗前后症状,体征,肝功能,HCV-RNA以及肝纤维化指标。结果:治疗组总有效率为80%,临床疗效与对照组差异无统计学意义(P>0.05);肝功能治疗前后比较,各自组内差异有统计学意义(P<0.05),组间比较无统计学意义(P>0.05);治疗组HCV-RNA阴转率为15%,对照组HCV-RNA阴转率为55%,差异比较有显著性统计学意义(P<0.01);治疗后,治疗组HA显著下降,两组比较差异有统计学意义(P<0.05),对照组CⅣ下降,但两组比较差异没有统计学意义(P>0.05)。结论:益肝饮对慢性丙型肝炎的保肝,降酶,抗纤维化作用较好,抗病毒效果与干扰素组有较大差距。Objective：To observe the clinical effect of the Yigan Yin in treating chronic hepatitis C. Methods ：40 patients of chronic hepatitis C were randomly divided into the treated group （20 cases） , control group （20 cases）, treated with the Yigan Yin, Interferon alfa - 2b combine ribavirin respectively, with six - months course, to observe the items of clinical symptoms, physical signs, hepatic function, hepatitis C virus RNA （HCV - RNA） and the serum fibrosis indexes. Result：The results showed that the total effective rate was 80% in the treatment group after treatment, and clinical effect was no significant with control group（ P 〉0.05 ）; Pre-and post-treatment the indices of hepatic function were compared, the difference was significant in each group（ P 〈 0.05 ）, and was not significant between two groups（ P 〉 0.05 ） ; The clearance rate of HCV - RNA of the treated group was 15%, and the clearance rate of HCV - RNA of the control group was 55%. The difference of two groups was obviously （P 〈 0.01 ）; After treatment, HA of the treated group decreased remarkably. There was statistical significance between two groups on HA（P 〈 0.05）. CIV of the control group reduced, however there was no difference in C1V of two groups（ P 〉 0.05）. Conclusion：To the patients of chronic hepatitis C, the Yigan Yin possess functions of protecting the hepatic cells, reducing en- zymes and resisting hepatic fibrogenesis. The functions of suppressing viral replication, clearing virus of the interferon combine ribavirin therapy are better than the Yigan Yin therapy.

关 键 词：益肝饮 慢性丙型肝炎 中医药疗法 对照观察 

分 类 号：R512.63[医药卫生—内科学]