药物变态反应好发因素的临床研究——病人因素  

Analysis of the Predisposing Factors in Drug Allergy-Patient Factor

作　　者：李世荫[1] 周劲松[1] 

机构地区：[1]北京医科大学第三临床学院皮肤科,呼和浩特100083

出　　处：《药物流行病学杂志》1997年第2期75-78,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：对516例经确认的药物变态反应(DA)住院病例,进行有关病人方面好发因素的分析和统计,并以204例非药物变态反应的住院病例为对照。发现儿童与老人发病率低,病人的过敏性疾病史和药物过敏史、原有的肝病及感染性疾病都与DA的发生显著相关。对异位性素质与速发型变态反应的关系,在临床分析后作了进一步研究,结果表明二者间无密切关系。文中并对多价过敏与某些慢性疾病的关系进行了讨论。The predisposing factors of 516 proved cases of drug allergy were analyzed and 204 subjects without drug allergy history were used as controls. Our results showed that incidence of drug allergy was low in children and the aged persons. The history of allergy, the presence of liver damage and infectious diseases were all related to the development of drug allergy. It was found that atopic diathesis was not closely associated with immedicate penicillin allergy. The relationship between multisensitivity and some chronic diseases were also discussed.

关 键 词：药物变态反应 好发因素 病人因素 

分 类 号：R595.3[医药卫生—内科学]