胎儿纤连蛋白对先兆早产孕妇发生早产的预测价值  

THE CLINICAL STUDY OF PRETERM BIRTH PREDICTION WITH FETAL FIBRONECTIN IN PREGNANT WOMEN WITH PRETERM LABOR

作　　者：焦红燕[1] 林慧芳[2] 王亚凡[1] 杨兰芝[3] 

机构地区：[1]石家庄市妇幼保健医院妇产科,河北石家庄050051 [2]石家庄市卫生局办公室,河北石家庄050021 [3]河北医科大学第二医院妇产科,河北石家庄050000

出　　处：《河北医科大学学报》2008年第6期837-838,共2页Journal of Hebei Medical University

摘　　要：目的研究胎儿纤连蛋白(fetal fibronectin,fFN)对先兆早产孕妇发生早产的预测价值,进而提出可能的干预措施。方法对126例有先兆早产症状的孕妇进行宫颈阴道部分泌物fFN的测量,追踪这些孕妇的妊娠结局。结果126例先兆早产孕妇中,78例fFN阳性,阳性率为61.9%,早产57例。fFN阳性孕妇7 d内、14 d内、37周前分娩率分别为25.6%、39.7%、69.2%,fFN阴性孕妇则分别为0%、0%、12.8%。对7 d内、14 d内和37周内分娩的阴性预测值分别为100%、100%和87.2%。结论先兆早产孕妇宫颈阴道部分泌物fFN阳性对早产的发生有一定的预测价值,但当fFN阴性对预测其短期内不发生早产的临床价值更大。Objective To determine the predictive value of fetal fibronectin （fFN） for preterm birth in pregnant women with preterm labor. Methods Fetal fibronectin in cervicovaginal secretions were measured in 126 pregnant women with preterm labor. Pregnant outcomes were recorded. Results Among 126 subjects, positive rate of fFN was 69.5% （78 cases）. Fifty seven cases were preterm labor. The prevalence of spontaneous preterm delivery among those women with fFN（＋） within 7 days, 14 days, and〈37 weeks were 25.6%, 39.7% and 69.2%, respectively,which were significantly higher than those women with fFN（-） （0%, 0% and 12.8%）. The negative predictive value were 100%, 100% and 87.2%. Conclusion Vaginal fetal fibronectin determination is valuable in predicting preterm birth in pregnant women with preterm labor,especially significant for negative predictive value.

关 键 词：胎儿 纤连蛋白类 早产 预测 

分 类 号：R714.2[医药卫生—妇产科学]