条件性味觉厌恶学习对大鼠丘脑脑区亮脑啡肽表达的影响  

Effect of Conditioned Taste Aversion Acquisition and Retention on the Expression of Endogenous Leu-enkephalin in the Rat Thalamus

作　　者：史玉兰[1] 白文忠[2] 张金平[3] 潘培森[1] 金凤霞[2] 

机构地区：[1]白求恩军医学院生理学教研室,河北石家庄050081 [2]河北师范大学生命科学学院动物生理教研室,河北石家庄050016 [3]河北医科大学组织学与胚胎学教研室,河北石家庄050017

出　　处：《苏州大学学报（医学版）》2008年第5期713-715,共3页Suzhou University Journal of Medical Science

摘　　要：目的观察条件性味觉厌恶学习(CTA)对亮脑啡肽(LEK)表达的影响。方法采用免疫细胞化学方法,观察LEK阳性神经元在大鼠脑内的分布情况,并比较建立CTA前后丘脑5个核团内内源性LEK的表达水平。结果CTA组大鼠丘脑外侧背核、丘脑内侧背核外侧部及丘脑腹后内侧核内LEK阳性神经元数目显著少于对照组,差异有统计学意义(P<0.05)。结论获得CTA的大鼠脑内的LEK表达水平均降低,提示脑内一些核团的LEK表达在CTA过程中发挥作用。Objective To investigate the effect of conditioned taste aversion （CTA） acquisition and retention on the expression of endogenous leu-enkephalin （LEK） in rats. Methods By using LEK immunocytoehemical staining, the expression of endogenous LEK was observed, and respectively, its expression in 5 parts of the thalamus is comparatively researched before and after the acquisition of CTA. Results Obviously, immunoreactive neurons in the laterodorsal thalamic nucleus, the lateral part of the mediodorsal thalamic nucleus and the ventral posteromedial thalamic nucleus decreased after CTA （P〈0.05）. Conclusion The decrease of LEK-expressive level in the brain in CTA group suggests that endogenous LEK in some nuclei may play an important role in the acquisition of CTA.

关 键 词：条件性味觉厌恶学习 亮脑啡肽 丘脑 

分 类 号：R338.6[医药卫生—人体生理学]