新型两亲性酞菁锌杀伤Bel-7402人体肝癌细胞研究  

Investigation of Damaging Effects of Amphipathy Phthalocyanine Zinc on Bel-7402 Human Liver Cancer Cells

作　　者：李晓丽[1] 陈伟[1] 李涛[2] 王玉[2] 夏春辉[2] 

机构地区：[1]齐齐哈尔大学化学化工学院,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院基础医学系,黑龙江齐齐哈尔161042

出　　处：《河北师范大学学报（自然科学版）》2008年第6期803-805,共3页Journal of Hebei Normal University：Natural Science

基　　金：黑龙江省教育厅科学技术研究项目(11511441);黑龙江省齐齐哈尔市重点科技项目(GY05-19SFG06-02);黑龙江省卫生厅科学技术研究项目(2005-333)

摘　　要：合成了新型两亲性α-四(对羟甲基苯氧基)酞菁锌(Ⅱ)光敏剂,采用UV-Vis、元素分析I、R、激光解吸电离飞行时间质谱(TOF-MS)对配合物进行了表征.在光诱导条件下,采用四甲基偶氮唑蓝比色法研究了此酞菁锌配合物对Bel-7402细胞抑制作用,考察了质量浓度对配合物的抑瘤效果的影响,确定其IC50值.结果发现:酞菁锌是一种很有潜力的抗癌光敏剂,并探讨了其抑瘤机制.A novel amphipathy α- tetra- [ （p-hydroxymethyl） phenoxy ] ] phthalocyanine zinc （ Ⅱ ） photosensi- tizer has been synthesized. It was characterized by using UV-Vis absorption spectra, IR spectra, elemental analysis and TOF-MS. The damaging effects of phthalocyanine complexe on human Bel-7402 liver cancer cell were in- vestigated by means of HE dye method and MTT colorimetric assay under condition of photoinduce. The influences of phthalocyanine complexe,s concentration on cancer inhibition were systemic studied, IC50 numerical value was ascertained. The results show that the phthalocyanine zinc（Ⅱ） is a kind of promising anticancer photosensitizer,exhibits good inhibition effects under appropriate concentration, and the inhibition mechanism was primarily discussed.

关 键 词：酞菁锌 光诱导杀伤 BEL-7402细胞 

分 类 号：O644.12[理学—物理化学] R735.7[理学—化学]