2-叔丁基-4-氟-苯并氧杂卓并[3,4-b]喹啉并[9,11]二氧戊环-14(6H)-酮的合成(英文)  

Synthesis of 2-tert-butyl-4-fluoro-benzoxepino [3,4-b]quinolino[9,11]dioxolane-14(6H)-one

作　　者：李阳[1] 张红[2] 常明琴[2] 高文涛[1] 

机构地区：[1]渤海大学超精细化学品研究所,辽宁锦州121000 [2]渤海大学化学化工学院,辽宁锦州121000

出　　处：《化学研究与应用》2008年第11期1491-1494,共4页Chemical Research and Application

基　　金：辽宁省教育厅资助项目(202142037)

摘　　要：以2-溴甲基-6,7-亚甲二氧基-3-喹啉酸乙酯(1)为原料,经三步合成了2-叔丁基-4-氟-苯并氧杂卓并[3,4-b]喹啉并[9,11]二氧戊环-14(6H)-酮(4)。其中,6-(2-氟-4-叔丁基-苯氧甲基)-[1,3]二氧戊环并[4,5-g]喹啉-7-羧酸是经一锅法合成的。它的分子内闭环反应是在Eaton’s reagent(P2O5-CH3SO3H)的作用下,在较温和的条件下进行的。所得新化合物3和4的结构经IR1、H NMR和元素分析得以证实。Quinoline-fused ring many natural products and systems are a back-bone of oharma compounds and display a broad activity. For example, the cologically significant range of biological anticancer alkaloid camptothecin （Figure 1 ） is used as medicine against gastric cancer,tumors of the neck and carcinoma of the urinary bladder. Quinoline derivatives represent the major class of heterocycles, and a number of preparations have been known since the late 1980s. The quinoline skeleton is often used for the design of many synthetic compounds with diverse pharmacological properties .

关 键 词：一锅法 喹啉 闭环 合成 伊藤试剂 

分 类 号：O626[理学—有机化学]