硒-甲基硒代半胱氨酸的合成与拆分研究  

Synthesis and resolution of Se-methylselenocysteine

作　　者：刘建群[1] 刘芳[2] 张小平 寇晓莉[1] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004 [2]江西萍乡高等专科学校化工系,江西萍乡337055 [3]江西川奇药业有限公司,江西南昌330029

出　　处：《化学研究与应用》2008年第11期1498-1501,共4页Chemical Research and Application

基　　金：南昌市科技型中小企业技术创新基金(2007)资助项目

摘　　要：2-Acetamidoacrylic acid or methyl 2-acetamidoacrylate is reacted with solution of sodium of methylselenol to give N-acetyl-Se-methylselenocysteine.The L(and D)-Se-methylselenocysteine have been prepared in high optical purity by treating N-acetyl-Se-methylselenocysteine in water using acylase I from porcine kidney as a catalyst.The influencing factors on the resolution reaction are discussed by orthogonal experiment,including pH value,reaction temperature,concentration of Co2+ and amount of acylase I.Under the optimizing resolution conditions,L(and D)-Se-methylselenocysteine are obtained with>96 % optical purity in about 40% yield.2-Acetamidoacrylic acid or methyl 2-acetamidoacrylate is reacted with solution of sodium of methylselenol to give N- acetyl-Se-methylselenoeysteine. The L（ and D）-Se-methylselenocysteine have been prepared in high optical purity by treating N- acetyl-Se-methylselenocysteine in water using acylase I from porcine kidney as a catalyst. The influencing factors on the resolution reaction are discussed by orthogonal experiment, including pH value, reaction temperature, concentration of Co2＋ and amount of acylase I. Under the optimizing resolution conditions, L（ and D）-Se-methylselenoeysteine are obtained with 〉 96 % optical purity in about 40% yield.

关 键 词：硒-甲基硒代半胱氨酸 2-乙酰氨基丙烯酸 2-乙酰氨基丙烯酸甲酯 合成 拆分 

分 类 号：O627.6[理学—有机化学]