Two new tetralone derivatives from the culture of Xylaria hypoxylon AT-028  

作　　者：Wen Gu Hui Ding 

机构地区：[1]Department of Forestry Chemieal Engineering, School of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

出　　处：《Chinese Chemical Letters》2008年第11期1323-1326,共4页中国化学快报（英文版）

摘　　要：Two new tetralone derivatives named xylariol A （1） and B （2） were isolated from the EtOAc extract of the culture broth of Xylaria hypoxylon AT-028 （Xylariaceae）, and their structures were elucidated by MS, 1R, 1D- and 2D-NMR spectra, and by X-ray diffraction analysis. 1 and 2 showed moderate cytotoxic activities against Hep G2 cells in the in vitro cytotoxic assay with IC50 values of 22.3 and 21.2 μg/mL, respectively.Two new tetralone derivatives named xylariol A （1） and B （2） were isolated from the EtOAc extract of the culture broth of Xylaria hypoxylon AT-028 （Xylariaceae）, and their structures were elucidated by MS, 1R, 1D- and 2D-NMR spectra, and by X-ray diffraction analysis. 1 and 2 showed moderate cytotoxic activities against Hep G2 cells in the in vitro cytotoxic assay with IC50 values of 22.3 and 21.2 μg/mL, respectively.

关 键 词：Xylaria hvpoxylon Xylariol A Xylariol B Cylotoxicity 

分 类 号：Q5[生物学—生物化学]