ILK/PI3K/PKB转导通路与肿瘤  

Transduction Pathway of ILK/PI3K/PKB and Tumor

作　　者：朱明艳[1] 冯虹[1] 

机构地区：[1]沈阳医学院奉天医院检验科,沈阳110024

出　　处：《医学综述》2008年第22期3411-3412,3434,共3页Medical Recapitulate

摘　　要：整合素连接激酶(ILK)以依赖于磷酯酰肌醇3-激酶(PI3K)方式激活,通过磷酸化下游底物蛋白激酶B(PKB)等使细胞外信号向下游传递,对细胞的生长、分化及细胞凋亡、细胞周期、细胞黏附等进行调控,在肿瘤的发生、发展中发挥着重要的作用。本文综述ILK/PI3K/PKB传导通路中一些酶类或基因在肿瘤中的表达及其与肿瘤发生、发展及治疗的研究进展。ILK is activated by PI3K, it can down-transmit extracellular signal by phosphorating downstream substrate protein kinase B （PKB） , then regulate the cell growth, cell differentiation, apoptosis, cell cycle and cell adhesion and play an important role in the genesis and development of tumor. This article reviews some enzymes or genes related to transduction pathway and its relationship with tumor genesis, gene development and treatment.

关 键 词：整合素连接激酶 磷脂酰肌醇3-激酶 蛋白激酶B 肿瘤 

分 类 号：R446.6[医药卫生—诊断学]