顺铂耳毒性机制及其防护的研究进展  

Research Advance in Mechanism and Prevention of Ototoxicity of Cisplatin

作　　者：孙伟霞[1] 王爱梅[1] 

机构地区：[1]辽宁医学院生理学教研室,辽宁锦州121001

出　　处：《医学综述》2008年第22期3477-3480,共4页Medical Recapitulate

基　　金：辽宁省教育厅科学研究计划资助(202173374);辽宁省博士科研启动基金项目(20031086)

摘　　要：顺铂是目前临床上常用的广谱高效抗癌药,但该药具有严重的耳不良反应,可造成双侧听力损失。本文就国内外近年对顺铂耳毒性的作用机制及其防护的研究进展予以综述。Cisplatin is a broad spectrum and high effect anticarcinogen, which is widely used in clinic practice. However, side effects in ears always occur in many patients treated with cisplatin, which can result in bilateral hearing loss. This article summarized the research progress in mechanism and prevention of ototoxicity of cisplatin.

关 键 词：顺铂 耳毒性 活性氧族 凋亡 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]