氰酸钠法合成磺酰脲类除草剂苄嘧磺隆  

Synthesis of Herbicide Bensulfuron-methyl by Sodium Cyanate Method

作　　者：王岩[1] 张伟[1] 

机构地区：[1]吉林农业大学资源与环境学院应用化学系,吉林长春130118

出　　处：《化学世界》2008年第11期685-687,共3页Chemical World

摘　　要：研究了以邻甲酸甲酯苄基磺酰氯、2-氨基-4,6-二甲氧基嘧啶和氰酸钠为原料,乙腈为溶剂,在吡啶催化下合成除草剂苄嘧磺隆的新方法。考察了溶剂种类、催化剂用量、氰酸钠用量、反应时间、反应温度等因素对反应的影响。结果表明:邻甲氧羰基苄基磺酰氯、2-氨基-4,6-二甲氧基嘧啶、吡啶和氰酸钠摩尔比为1∶1∶1∶1.2,乙腈为溶剂,在40°C下搅拌反应3 h,产品收率67.8%,纯度97.0%(HPLC)。该方法避免了剧毒光气,简化了工艺路线,是一个对环境友好的磺酰脲除草剂的合成方法。Herbicide bensulfuron-methyl was prepared by reaction of methyl 2-（chlorosulfonylmethyl） benzoate with sodium cyanate and 2-amino-4, 6-dimethoxypyrimidine in the presence of pyridine as a catalyst in acetonitrile. The effects of kind of solvent, amounts of catalyst and sodium cyanate, reaction time and reaction temperature were studied. The optimum conditions are as follows： molar ratio of methyl 2-（chlorosulfonylmethyl） benzoate ： g-amino-4,6-dimethoxypyrimidine ： pyridine ： sodium cyanate=1 ： 1 ： 1 ： 1.2, acetonitrile as a solvent, reaction time 3 h, reaction temperature 40℃. The yield and purity of product is 67.8%, and 97% （HPLC）, respectively. The method can secure from using phosgene and the process is simple. It is a green chemical method for preparation of sulfonylurea herbicides.

关 键 词：除草剂 苄嘧磺隆 合成 氰酸钠 

分 类 号：TQ460.3[化学工程—制药化工]