易损斑块与内皮祖细胞研究进展  

Relationship Between Vulnerable Plaque and Endothelial Progenitor Cells

作　　者：张丽洁[1] 吕树铮[1] 

机构地区：[1]首都医科大学附属北京安贞医院心内科,北京100029

出　　处：《心血管病学进展》2008年第6期854-857,共4页Advances in Cardiovascular Diseases

基　　金：北京市科技计划项目(D0906006000091)

摘　　要：研究证实易损斑块出现的同时伴随着内皮功能紊乱、内皮细胞脱失以及炎症反应的存在。内皮受损后可引起炎症反应激活、单核细胞浸润和血管平滑肌细胞增生,进而促发动脉粥样硬化和再狭窄形成,故修复受损血管内皮、促使血管重新内皮化已经成为防止动脉粥样硬化及再狭窄领域的重要课题。与此同时,内皮祖细胞参与受损血管的重新内皮化,吸引了越来越多的关注。现就内皮祖细胞与易损斑块的研究进展进行综述。It has been confirmed that the occurrence of endothelial dysfunction, the loss of endothelial cells, and an inflammatory reaction is always accompanied by the appearance of vulnerable plaque. After the endothelium has been injured, inflammatory reactions are activated; at the same time, mononuclear cells infiltrate into the tunica intima and the vascular smooth muscle proliferate, which induces atherosclerosis and restenosis. Therefore, the most important issues facing this area are how to repair the injured endothelium, and how to accelerate vascular reendothelialization. In addition, increased attention is being given to the use of endothelial progenitor ceils to help reendothelialize vascular tissue. This article reviews recent research related to vulnerable plaque and endothelial progenitor cells.

关 键 词：易损斑块 内皮祖细胞 内皮功能紊乱 内皮修复 

分 类 号：R543[医药卫生—心血管疾病]