成熟心肌细胞有丝分裂周期调控的研究进展  

Cell Division and Regeneration of Adult Cardiomyocyte

作　　者：刘司寰[1] 马建旸[2] 

机构地区：[1]四川大学华西医院急诊科,四川成都610041 [2]四川大学华西医院胸心外科,四川成都610041

出　　处：《心血管病学进展》2008年第6期910-913,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金资助项目(30500497)

摘　　要：传统认为,哺乳动物心脏细胞在出生后不久即失去了有丝分裂的能力,成为终末分化的有丝分裂后细胞。然而,近年来的研究表明,人类心脏完全有可能在损伤一段时间后通过心肌细胞分裂和再生进行自然的修复。在心肌细胞蛋白分子和基因水平进行调节,重新激活和提高心肌细胞的分裂和增生的潜能,以替代坏死及纤维化的心肌细胞,有望成为缺血性心脏病、心力衰竭等疾病患者促进心脏自我修复,改进心脏功能的新治疗方向。It is generally believed that cardiomyocytes withdraw from the cell cycle during the perinatal period, at which point the heart becomes a postmitotic and differentiated organ. This notion, however, is challenged by the results of recent studies that show a considerable amount of cardiomyocyte cell division and regeneration in the failing and infarcted human myoeardium. Augmenting cardiomyoeyte numbers by targeting specific cell cycle regulatory genes may be of therapeutic value in repopulating the adult myocardium with functionally active cells in patients with ischemie heart disease and end-stage heart failure. Advancements in the area of cardiomyocyte cell cycle control and regeneration and their therapeutic potential are reviewed in this article.

关 键 词：心肌细胞 再生 细胞周期 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]