复方甘草酸苷治疗抗结核药物性肝炎的疗效观察  

Therapeutic Effects of Compound Glycyrrhizin on Patients with Hepatitis Induced by Anti-tuberculosis Drugs

作　　者：谢俊平[1] 陈创坤 

机构地区：[1]广东省汕头市澄海区人民医院内二科,广东汕头515800

出　　处：《河北医学》2008年第11期1286-1289,共4页Hebei Medicine

摘　　要：目的:探讨复方甘草酸苷在治疗抗结核药物性肝炎中的作用。方法:选择结核病治疗中发生药物性肝炎并停用抗结核治疗药物患者48例,随机分为治疗组24例(常规治疗+复方甘草酸苷:复方甘草酸苷注射液60 ml加5%葡萄糖注射液250ml,静脉滴注,每日1次)和对照组24例(常规治疗组),4周为1疗程;对两组患者肝损害情况(ALT、AST、T-BIL)及预后进行观察比较。结果:两组患者症状、体征的恢复无明显差异(P>0.05)。治疗组显效及有效24例(100.0%),对照组显效及有效19例(79.2%),治疗组肝功能损害恢复情况优于对照组,两组差异显著(P<0.05))。结论:在结核患者进行抗结核治疗过程中,应加强肝功能监测;复方甘草酸苷治疗抗结核药物引起的药物性肝炎疗效显著。Objective： To investigate the efficacy of compound glycyrrhizin on patients with hepatitis associated with anti - tuberculosis drugs. Methods ：48 inpatients with hepatitis due to anti - tuberculosis drugs were randomly divided into two groups： treatment group （24 patients ）received routine therapy plus compound glycyrrhizin ： compound glycyrrhizin for injection 60 ml and control group （24 patients ） received routine therapy for 4 5% glucose weeks. The solution 250 ml （ iv gtt, qd ）. The damages of hepatic funtion （ ALT, AST, T- BIL ） and prognosis were observed and compared between the two groups. Results ：The recovery of symptoms and signs were not＇ different significantly between the two groups （ p 〉 0.05 ）. 24 cases patients （ 100% ） have completely or partly response in the treatment group, while 19 cases patients （79.2% ） have completely or partly response in the control group. The recovery of hepatic function is superior in the treatment group compared with the control group （ p 〈 0.05 ）. Conclusion： Hepatic function must be detected strengthly among the therapy of anti - tuberculosis; the efficacy of compound glycyrrhizin on patients with hepatitis associated with anti -tuberculosis drugs is significant.

关 键 词：结核病 药物性肝损害 复方甘草酸苷 

分 类 号：R595.3[医药卫生—内科学] R575.1[医药卫生—临床医学]