病毒感染在慢性阻塞性肺疾病急性加重中的作用  

Effect of viral infection on the acute exacerbation of chronic obstructive pulmonary disease

作　　者：崔文洁[1] 丁宁[1] 周宁[1] 

机构地区：[1]徐州市第一人民医院呼吸内科,江苏徐州221002

出　　处：《徐州医学院学报》2008年第11期712-715,共4页Acta Academiae Medicinae Xuzhou

摘　　要：目的探讨常见呼吸道病毒感染在慢性阻塞性肺疾病急性加重(AECOPD)中的作用。方法选择AECOPD患者116例,检测呼吸道病毒抗原及特异性IgM抗体,根据结果分为病毒阳性组及病毒阴性组。并对病毒阳性组与阴性组进行T淋巴细胞亚群检测。结果116例AECOPD患者共检测出病毒阳性41例,阳性率为35.34%。与病毒阴性组比较,病毒阳性组CD4+T淋巴细胞降低,CD8+T淋巴细胞升高,CD4+/CD8+比值下降,差异有统计学意义(P<0.05或P<0.01)。结论AECOPD与呼吸道病毒感染有关。病毒感染对T淋巴细胞亚群有抑制作用,导致机体细胞免疫功能低下。Objective To investigate the effect of viral infections of the respiratory tract on the acute exacerbation of chronic obstructive pulmonary disease. Methods Samples from 116 patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） were tested for respiratory virus antigen and the specific IgM antibody for respiratory viruses. According to the results, patients were divided into virus - positive group and virus - negative group and their T lymphocyte subsets were tested and compared. Results Of the 116 AECOPD patients, 41 patients were found virus - positive, with a virus - positive percentage of 35.34%. In virus - positive group, the expressions of CD4 ^＋ , CD4 ^＋ / CD8 were significantly lower than those in virus - negative group, with a higher CD8 ^＋ than in virus - negative group （ P 〈 0.05,P 〈 0.01 ）. Conclusion The AECOPD patients were related to viral infections of the respiratory tract. T lymphocyte subsets were associated with viral infections. The results also showed that viral infections could decrease immune functions and lead to immunologic aberration.

关 键 词：慢性阻塞性肺疾病急性加重 呼吸道病毒 免疫功能 

分 类 号：R562[医药卫生—呼吸系统]