正交试验设计优选咽清颗粒的提取工艺  

Optimization of Extraction Technology of Yanqing Granule by Orthogonal Test

作　　者：崔晶[1] 赵宇[2] 边逸群[2] 周文[1] 

机构地区：[1]山东大学齐鲁医院药剂科,山东济南250012 [2]山东大学药学院,山东济南250012

出　　处：《食品与药品》2008年第6期29-31,共3页Food and Drug

摘　　要：目的通过正交试验设计考察咽清颗粒的提取工艺。方法以总浸膏量和有效成分绿原酸含量为指标,以溶剂量、提取时间和提取次数为考察因素,每因素设计3个水平,用L 9(3 4)正交表安排试验。结果咽清颗粒的最佳提取工艺为1/3处方量的药材以200 mL水回流提取3次,每次0.5 h。结论确定的咽清颗粒提取工艺重复性好,操作简单,具有较高的应用价值。Objective To optimize the extraction technology of Yanqing Granule by orthogonal test. Methods Using the contents of chlorogenic acid and total extraction as indexes, choosing solvent volume, extracting duration and extracting times as influential factors, the optimal extraction condition was studied by L9（3^4） orthogonal test. Results The optimal extraction condition of Yanqing Granule was： 200 mL water for 1/3 amount of drugs, refluxing extraction for 3 times and 0.5 h each time. Conclusion The optimal extraction technology obtained in this study is simple and reproducible, and it has a higher application value in the production of Yanqing Granule.

关 键 词：咽清颗粒 正交试验 绿原酸 高效液相色谱法 

分 类 号：R282.71[医药卫生—中药学]