痛风饮对实验性急性痛风性关节炎大鼠抗炎镇痛作用机制的研究  

Study on the Anti-inflammtory Analgesic Effects of Tongfengyin on Acute Gouty Arthritis

作　　者：杨洪霞[1] 杨丽芸[1] 张灵敏[2] 靳红微[1] 

机构地区：[1]河北医科大学中医学院,河北石家庄050091 [2]河北医科大学研究生学院,河北石家庄050017

出　　处：《时珍国医国药》2008年第11期2784-2786,共3页Lishizhen Medicine and Materia Medica Research

摘　　要：目的研究民间验方痛风饮1付对急性痛风性关节炎的抗炎镇痛作用机制。方法通过对痛风模型大鼠应用痛风饮观察急性痛风性关节炎大鼠患肢压力及步态积分;踝周径变化值;检测白细胞,中性粒细胞,血清IL-1β、IL-6水平;以及右踝关节组织HE染色。结果痛风饮能明显减轻实验性大鼠踝关节肿胀程度,以及患肢站立及行走时压力积分,能降低白细胞、中性粒细胞及IL-1β、IL-6水平,具有改善致炎关节滑膜细胞增生和减轻炎细胞浸润的作用。结论痛风饮具有抗炎镇痛作用。Objective To observe the anti - inflammatory analgesic effects of Tongfengyin 1 on acute gouty arthritis. Methods Observed gouty arthritis in rats limb pressure points, gait, foot swelling, measured the levels of WBC, neutrophil, IL - 1 β, IL -6, did hematoxylin - Yihong （which was abbreviated to HE） staining to the tissues of fight ankle joint acquired. Results Tongfengyin could significantly reduce the gouty arthritis in rats limb pressure points, gait, foot swelling, and reduce the levels of WBC, neutrophil and IL - 1β, IL - 6, improve the synovial lining layer hyperplasia and reduce the inflammatory cells. Conclusion Tongfengyin is effective on antiinflammation and analgesia.

关 键 词：痛风饮 急性痛风性关节炎 微晶钠 白细胞 中性粒细胞 白细胞介素-1Β 白细胞介素-6 

分 类 号：R255.6[医药卫生—中医内科学]