依达拉奉对百草枯中毒致急性肺损伤预防及治疗作用研究  

The study of preventive and therapeutic effects of edaravone against paraquat-induced acute lung injury

作　　者：尤再春[1] 史忠[1] 高全杰[1] 周坤[1] 李霞[1] 卢玉宝[1] 

机构地区：[1]第三军医大学新桥医院急救部,重庆400037

出　　处：《重庆医学》2008年第22期2517-2519,共3页Chongqing medicine

摘　　要：目的探讨依达拉奉注射液对百草枯中毒致急性肺损伤的预防及治疗作用。方法将2006年2月至2008年2月收治的30例百草枯中毒患者随机分为依达拉奉治疗组(A组,16例)和对照组(B组,14例)。检测血浆丙二醛(MDA)、超氧化物歧化酶(SOD)、谷光甘肽过氧化物酶(GSH-px)含量来评定氧自由基水平及自由基清除系统活性。结果A组与B组比较,血浆中MDA含量下降,SOD和GSH-px活力升高(P<0.01)。结论依达拉奉可以预防及治疗百草枯中毒引起的急性肺损伤。Objective To study the preventive and therapeutic effects of edaravone against paraquat-induced acute lung injury. Methods Thirty paraquat poisioning patients between Feb 2003 and Feb 2008 in our hospital were divided into A group （n=16, treated with edaravone） and 13 group （n= 14, treated with conventional therapy）. The plasma level of malonaldehyde （MDA）, superoxide dismutase （SOD） ,and glutathione peroxidase （GSH-px） were measured. Results Comparing with those of B group,MDA level decreased and SOD, GSH-px increased significantly in A group （P〈0. 01）. Conclusion Edaravone exerts preventive and therapeutic effects on paraquat-induced acute lung injury.

关 键 词：依达拉奉 百草枯中毒 急性肺损伤 

分 类 号：R595.4[医药卫生—内科学]